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中国临床药理学与治疗学 ›› 2004, Vol. 9 ›› Issue (11): 1253-1255.

• 研究原著 • 上一篇    下一篇

氮酮和薄荷醇对联苯苄唑体外经皮渗透性的影响

刘焕龙, 冯小龙1, 王新宇2   

  1. 河北医科大学第二医院药剂科,石家庄 050000,河北;
    1中奇制药技术(石家庄)有限公司药理室,石家庄 050051河北;
    2华北制药康欣有限公司,石家庄 050017,河北
  • 收稿日期:2004-08-25 修回日期:2004-09-23 出版日期:2004-11-26 发布日期:2020-11-19
  • 通讯作者: 冯小龙,男,硕士,研究方向:皮肤药理学、药代动力学。Tel: 0311-7896836 E-mail:fxll5@vip.sina.com
  • 作者简介:刘煥龙,男,学士,研究方向:临床药学。

Effects of 1-menthol and azone on percutaneous penetration of bifonazole in vitro

LIU Huan-Long, FENG Xiao-Long1, WANG Xin-Yu2   

  1. Department of Pharmacy, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei, China;
    1Department of Pharmacology, Zhongqi Pharmaceutical Technology CO., LTD, Shijiazhuang 050051, Hebei, China;
    2North China Pharmaceutical Kanxin Co., LTD, Shijiazhuang 050017, Hebei, China
  • Received:2004-08-25 Revised:2004-09-23 Online:2004-11-26 Published:2020-11-19

摘要: 目的: 研究透皮促进剂氮酮和薄荷醇对外用抗真菌药联苯苄唑体外经皮渗透性影响。方法: 在离体透皮实验装置上进行透皮吸收试验和贮库效应的研究,采用正交函数分光光度法消除皮肤浸出物的吸收干扰。结果: 1%氮酮明显促进联苯苄唑经皮渗透作用,并可明显缩短时滞而增加贮库效应。结论: 氮酮对亲脂性极强的药物联苯苄唑的促透皮吸收作用较强,而薄荷醇无明显的促透作用,但可增加贮库效应。

关键词: 氮酮, 薄荷醇, 联苯苄唑, 经皮渗透, 正交函数分光光度法

Abstract: AIM: To investigate the effects of pene-tration enhancer 1-menthol and azone on percutaneous ab-sorption of bifonazole in vitro. METHODS: Percutane-ous penetration experiment was performed on device in vitro and deposit effect was observed by vivo perception. Orthogonal function spectrophotomery was used for obliter-ating the interferance of absorption RESULTS: Azone (1%) had a significantly effect on percutaneous absorption of bifonazole. The lag times were shortened and the deposit effect was increased by azone. CONCLUSION: Azone can enhance the percutaneous absorption of bifon-azole. Menthol can not enhance the percutaneous absorp-tion of bifonazole, but it can increase the deposit effect.

Key words: 1-menthol, azone, bifonazole, percuta-neous absorption, orthogonal function spectrophotomery

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