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中国临床药理学与治疗学 ›› 2004, Vol. 9 ›› Issue (12): 1321-1326.

• 综述 •    下一篇

抗抑郁药的信号转导机制

刘艳梅, 祁红, 陈红专   

  1. 上海第二医科大学药理学教研室, 上海 200025
  • 收稿日期:2004-10-01 修回日期:2004-11-23 出版日期:2004-12-26 发布日期:2020-11-19
  • 通讯作者: 陈红专, 男, 教授, 博士研究生导师, 主要从事神经药理学和临床药理学的研究。Tel:021-63846590-776451 E-mail:yaoli@shsmu.edu.cn
  • 作者简介:刘艳梅, 女, 硕士研究生, 研究方向:神经药理学。Tel:021-63846590-776450 E-mail:lovelymickey25@163.com

Signal transduction mechanism of antidepressant action

LIU Yan-Mei, QI Hong, CHEN Hong-Zhuan   

  1. Department of Pharmacology, Shanghai Second Medical University, Shanghai 200025, China
  • Received:2004-10-01 Revised:2004-11-23 Online:2004-12-26 Published:2020-11-19

摘要: 抗抑郁药的作用机制目前尚不明确, 传统单胺递质理论和受体理论都不能充分解释抗抑郁药的临床效应滞后现象。近年提出抗抑郁药的信号转导机制, 认为抗抑郁药是以G 蛋白为分子基础, 神经递质受体和G 蛋白为作用环节, 最终影响细胞内的信号转导并产生磷酸化作用增加、神经营养因子增多、神经发生增加等相关效应, 从而发挥抗抑郁作用。影响细胞内信号转导并产生相关效应需要的时间, 与抗抑郁药的临床效应滞后时间相吻合, 从而使抗抑郁药的滞后现象有了合理解释。这个机制的提出有助于抗抑郁新药的发展, 为研制安全、有效的新药指明了方向, 同时也为抑郁症生物学病因的阐明提供了必要信息。

关键词: 抗抑郁药, 信号转导, 环磷酸腺苷, G 蛋白, β-肾上腺素受体

Abstract: The mechanisms of antidepressants are still unclear.There are two classical theories on monoamine neurotransmitter or on neurotransmitter receptors, but both of them can not fully explain the delayed therapeutic action of antidepressants.Recently, many researches have focused on the postreceptor intracellular signal transduction as the mechanism of antidepressant action.G protein is the molecular basis of antidepressants. Neurotransmitter receptors and G protein are the two sectors of their therapeutic action.They will ultimately influence intracellular signal transduction and result in relative effects such as phosphoration, the induction of neurotrophic factors and neurogenesis.This mechanism suggests a reasonable explanation for the clinical delaying of antidepressants and it will do great help for the development of antidepressants.It makes the design of novel, safe and more efficacious antidepressants possible and provides significant information for the elucidation of biology of depression.

Key words: antidepressants, signal transduction, cAMP, G proteins, β-adrenergic receptor

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