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中国临床药理学与治疗学 ›› 2004, Vol. 9 ›› Issue (12): 1420-1423.

• 研究原著 • 上一篇    下一篇

阿司匹林-烟酰胺-锌络合物镇痛抗炎作用的实验研究

蒲其松, 雷军, 张翔   

  1. 川北医学院药理教研室, 南充 637000, 四川
  • 收稿日期:2004-10-04 修回日期:2004-11-25 出版日期:2004-12-26 发布日期:2020-11-19
  • 通讯作者: 蒲其松, 男, 副教授, 主要从事水杨酸类解热镇痛药的研究与开发。Tel:0817-2242761 E-mail:puqisong@yahoo.com.cn
  • 基金资助:
    国家重点科技攻关项目(No96-901-05-61)

Experimental studies on analgesic and anti-inflammation effects of aspirinniacinamide-zinc complex (WUY)

PU Qi-Song, LEI Jun, ZHANG Xiang   

  1. Department of Pharmacology, North Sichuan Medical College, Nanchong 637000, Sichuan, China
  • Received:2004-10-04 Revised:2004-11-25 Online:2004-12-26 Published:2020-11-19

摘要: 目的: 对阿司匹林-烟酰胺-锌络合物(WUY)的镇痛和抗炎作用进行初步研究。方法: 采用小鼠耳廓肿胀、腹腔毛细血管通透性增加以及大鼠足跖肿胀法研究抗炎作用, 小鼠热板法和扭体法研究镇痛作用。结果: WUY 中、高剂量组的耳廓肿胀度分别为3.3 和2.8 mg, 伊文思蓝渗出量分别为3.1 和1.2 mg·L-1, 足跖肿胀度(1~4 h) 分别为0.21~0.13 和0.23~0.08 ml 。小鼠热板法可明显延长热痛反应潜伏期, 提高小鼠的痛阈值。醋酸扭体法显示WUY 对小鼠扭体反应次数有明显抑制作用, 且比阿司匹林(ASP) 强。结论: WUY 具有比ASP 更强的镇痛和抗炎作用。

关键词: 阿司匹林-烟酰胺-锌络合物, 阿司匹林, 镇痛, 抗炎

Abstract: AIM: To study the analgesia and anti-inflammation effects of aspirin-niacinamide-zinc complex (WUY).METHODS: In this study, the mice ear swelling, vascular permeability increasing and rats'paw edema were adopted to evaluate the anti-inflammable effects of WUY.And the analgesic effects of WUY were tested by writhing reaction and hot-plate method.RESULTS: In high and low dose groups of WUY, the degrees of ear swelling were 3.3 and 2.8 mg·kg-1) prolonged incubation period of hot-plate reaction and showed marked inhibition effects on writhing induced by acetic acid in mice.CONCLUSION: The analgesic and antiinflammable effects of WUY are stronger than that of ASP.

Key words: aspirin-niacinamide-zinc complex, aspirin, analgesia, anti-inflammation

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