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中国临床药理学与治疗学 ›› 2004, Vol. 9 ›› Issue (2): 174-175.

• 研究原著 • 上一篇    下一篇

甘西鼠尾草注射液与丹参注射液对化学性缺氧小鼠能量代谢影响的比较

罗慧英, 程体娟   

  1. 兰州医学院药理教研室, 兰州, 730000, 甘肃
  • 收稿日期:2003-08-18 修回日期:2003-11-18 出版日期:2004-02-26 发布日期:2020-11-16
  • 通讯作者: 程体娟,女, 硕士, 教授, 硕士生导师, 研究方向:中药药理。Tel:0931-8615389  E-mail: chengtij@hotmail.com
  • 作者简介:罗慧英, 女, 硕士研究生。
  • 基金资助:
    甘肃省教育厅2001 年一般性科研项目(NO.013-01)

Comparison of energy metabolism on brain lacking oxygen between Salvia miltiorrhiza Bunge injection and Salvia przewalskii Maxim injection in mice

LUO Hui-Ying, CHENG Ti-Juan   

  1. Department of Pharmacology, Lanzhou Medical College, Lanzhou 730000, Gansu, China
  • Received:2003-08-18 Revised:2003-11-18 Online:2004-02-26 Published:2020-11-16

摘要: 目的: 比较甘西鼠尾草注射液与丹参注射液对急性化学性缺氧小鼠能量代谢的影响。方法: 通过注射NaNO2 造成小鼠急性化学性缺氧, 记录小鼠存活时间, 用ATPase 、LD 检测试剂盒分别检测脑组织中Na+-K+-ATPase 、Ca2+-ATPase 和乳酸(LD) 含量, 比较两药对能量代谢的影响。结果: 两药均可延长化学性缺氧小鼠存活时间, 增强Na+-K+-ATPase 。Ca2+-ATPase 活力, 降低LD 含量, 其中大剂量甘西鼠尾草注射液较大剂量丹参注射液更能增强Na+-K+-ATPase 活力, 而小剂量的甘西鼠尾草注射液在增强Ca2+-ATPase 活力上较小剂量的丹参注射液作用更强;在降低缺氧小鼠脑组织LD 含量方面, 两药作用基本相似。结论: 丹参注射液和甘西鼠尾草注射液对缺氧小鼠的能量代谢均有改善作用。两药均可延长缺氧小鼠存活时间, 降低脑组织LD 含量, 提高ATPase 活力, 但甘西鼠尾草注射液在提高ATP 酶活力方面优于丹参注射液。

关键词: 甘西鼠尾草注射液, 丹参注射液, 急性化学性脑缺氧, Na+-K+-ATPase, Ca2+-ATPase, LD

Abstract: AIM: To compare the influence of salvia miltiorrhiza Bunge njection (SMBI) and salvia przewalskii Maxim injection (SPMI) on energy metabolism of acute brain lacking oxygen.METHODS: The whole brain lacking oxygen model was made by injecting NaNO2 in mice and then wrote down the existent time of mice and detected the contents of Na+-K+-ATPase, Ca2+-ATPase and lactic acid (LD) in the brain.RESULTS: SMBI and SPMI both significantly lengthened the existent time of mice with the whole brain lacking oxygen, decreased the contents of LD and increased the activity of ATPase in mice.In increasing the activity of ATPase, the influence of SPMI was more than that of SMBI (P<0.05), but there was no significant difference between two injections in decreasing the contents of LD (P >0.05).CONCLUSION: SMBI and SPMI have distinctive protection on energy metabolism of acute brain lacking oxygen.Both of them can lengthen the existent of mice, reduce the contents of LD in brain and increase the activity of ATPase, but SPMI is more excellent than SMBI in increasing the activity of ATPase.

Key words: salvia miltiorrhiza Bunge injection(SMBI), salvia przewalskii Maxim injection (SPMI)acute brain lacking oxygen, Na+-K+-ATPase, Ca2+-ATPase, laitic acid

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