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中国临床药理学与治疗学 ›› 2004, Vol. 9 ›› Issue (5): 558-560.

• 研究原著 • 上一篇    下一篇

川芎嗪注射液对离体豚鼠气管平滑肌作用机制探讨

杨燕秋, 黎锐发, 许继德, 方茅, 吴秸, 黄文娴   

  1. 广州医学院生理教研室, 广州510182, 广东
  • 收稿日期:2003-11-19 修回日期:2004-03-19 发布日期:2020-11-22
  • 通讯作者: 许继德, 男, 副教授, 主要从事呼吸生理学研究。Tel:020-81340199  E-mai l:xujide @163.com
  • 作者简介:杨燕秋, 男, 本科。E-mail:doctoryyq @hotmail.com

Effects of tetramethylpyazine injection on isolated tracheal smooth muscles of guinea pigs

YANG Yan-Qiu, LI Riu-Fa, XU Ji-De, FANG Mao, WU Jie, Huang Wen-Xian   

  1. Department of Physiology, Guangzhou Medical College, Guangzhou 510182, Guangdong, China
  • Received:2003-11-19 Revised:2004-03-19 Published:2020-11-22

摘要: 目的 研究川芎嗪对离体豚鼠气管平滑肌的作用及机制。 方法 取豚鼠气管制成气管片, 用体外实验方法分别记录川芎嗪对豚鼠气管平滑肌的作用以及在钙通道和不同受体阻断剂孵育的条件下对豚鼠气管平滑肌的作用的变化。 结果 川芎嗪对离体豚鼠气管平滑肌有明显的舒张作用(P <0.01), 呈剂量依赖性(10-5.5 ~ 10-3 mol·L-1), 其作用可以被普萘洛尔(心得安) 所拮抗;其与硝苯地平有协同舒张气管平滑肌的作用;M 受体阻滞剂阿托品对川芎嗪的作用无明显影响。 结论 川芎嗪对离体豚鼠气管平滑肌有明显的舒张作用, 其机制很可能是通过作用于气管平滑肌上的β2 受体, 抑制细胞外Ca2+的内流而导致气管平滑肌的舒张。

关键词: 川芎嗪, 离体气管平滑肌, 豚鼠, 药理研究, β2 受体, Ca2+通道

Abstract: AIM: To investigate the effects of tetramethylpyazine (TMP) on isolated trachea of guinea pigs. METHODS: The contraction effects were observed from the isolated tracheal smooth muscles. RESULTS: TMP had a significant relaxing effect of concentration-dependent on isolated tracheal smooth muscles and the effect was antagonized by propranolol.It had also obvious synergism to nifedipine in the direct relaxation to the isolated tracheal smooth muscles.Atropine had no effect on the relaxation of the TMP. CONCLUSION: TMP has a significant relaxing effect on isolated tracheal smooth muscles of guinea pigs.The effect is related with β2 receptors and inhibiting calcium inflow.

Key words: tetramethypyazine, isolated tracheal smooth muscles, guinea pig, pharmacology, β2 receptor, calcium channel

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