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中国临床药理学与治疗学 ›› 2004, Vol. 9 ›› Issue (6): 705-708.

• 研究原著 • 上一篇    下一篇

华法林负荷量法抗凝治疗短暂性脑缺血发作的研究

罗伟良, 徐剑斌, 黄林辉, 许南燕, 邱金华, 刘武   

  1. 广东惠州市中心人民医院神经内科, 惠州516008, 广东
  • 收稿日期:2004-03-01 修回日期:2004-03-29 发布日期:2020-11-22
  • 通讯作者: 罗伟良,男, 副主任医师, 从事脑血疾病的基础和临床研究。Tel:0752-2288161  E-mai l:loui sweiliangluo @hotmail.com

Study on safety and efficiency of oral anticoagulation in patients with transient ischemic attack

LUO Wei-Liang, XU Jian-Bin, HUANG Lin-Hui, XU Nan-Yan, QU Jing-Hua, LIU Wu   

  1. Department of Neurology, Huizhou City Central People Hospital, Huizhou 516008, Guangdong, China
  • Received:2004-03-01 Revised:2004-03-29 Published:2020-11-22

摘要: 目的 观察华法林抗凝治疗短暂性脑缺血发作(TIA) 的安全性和疗效。 方法 2003 年1 月至2004 年1 月入院的TIA 病人, 适合抗凝治疗者, 按Roberts 依年龄调整华法林负荷量指南用药, 对照组为2002 年1 月至2003 年1 月住院的TIA 病人, 并剔除用肝素治疗的病人。 结果 华法林组10 d 内无脑卒中发生, 仅有4 人次再次TIA, 未发现有出血者;对照组10 d 内脑梗死6 例, 再次TIA 12 人次, 华法林组于TIA 发作后10 d 内发生脑梗死及再次TIA较对照组低(P <0.05)。 结论 按Roberts 华法林负荷量指南抗凝治疗TIA 优于非抗凝治疗, 而且安全。

关键词: 短暂性脑缺血发作, 华法林, 负荷量法, 抗凝治疗

Abstract: AIM: To evaluate the safety and efficiency of oral anticoagulation in patients with transient ischemic attack (TIA). METHODS: The hospitalized patients with TIA were treated by oral anticoagulation according to Roberts'age adjustedWarfarin loading protocol from February of 2003 for 12 months.The cases in control group were those with TIA except those having been used heparin from February of 2002 till January of 2003. RESULTS: Compare the two groups with average age, rate of gender, rate of cases complicated cardiac disease, hypertension and diabetes, blood pressure, cholestein, and triglyceride.There was no significant difference in all general conditions between two groups (P >0.05).However, there was no patient with the anticoagulation to develop stroke and hemorrhage in following days, but there were 6 cases had acute ischemic stroke in control group after that (P <0.05). CONCLUSION: Oral anticoagulation by using Roberts'Warfarin dosing guidelines is safe and more effective in patients with TIA.

Key words: transient ischemic attack (TIA), warfarin, loading dose, anticoagulation

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