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中国临床药理学与治疗学 ›› 2004, Vol. 9 ›› Issue (8): 841-844.

• 综述 •    下一篇

调节高密度脂蛋白药物研究进展

李勤凯 综述, 尹卫东 审校   

  1. 南华大学生命科学与技术学院, 衡阳421001, 湖南
  • 收稿日期:2004-05-31 修回日期:2004-07-16 出版日期:2004-08-26 发布日期:2020-11-20
  • 通讯作者: 尹卫东,男,博士,教授,博士生导师,研究方向:糖尿病的分子机制。Tel:0734-8282554 E-mail:wdy20012001@yahoo.com
  • 作者简介:李勤凯,男,硕士研究生,研究方向:高密度脂蛋白亚型分析。Tel:0734-8287250 E-mail:liqink2008@sina.com

Progress on the drugs for regulating high-density lipoprotein

LI Qin-Kai, YIN Wei-Dong   

  1. Department of Life Science and Technology, Nanhua University, Hengyang 421001, Hunan, China
  • Received:2004-05-31 Revised:2004-07-16 Online:2004-08-26 Published:2020-11-20

摘要: 动脉粥样硬化(atherosclerosis,AS)是许多心血管疾病的主要病理基础之一,提高高密度脂蛋白水平具有显著的抗AS 作用,该类药物的作用机制包括:胆固醇酯转运蛋白(cholesterol ester transfer protein,CETP)抑制剂、过氧化体增殖物激活型受体(peroxisomal proliferator-activated receptors,PPARs)激动剂、肝脏X 活化受体(liver X-activated receptor,LXR)激动剂、法尼酯衍生物X 受体(farnesoid X receptor,FXR)拮抗剂 激动剂、脂蛋白脂酶(lipoprotein lipase,LPL)活化剂、烟酸类、苯妥英、卵磷脂胆固醇酰基转移酶(lecin :cholesterol acyltransferase,LCAT)活化剂等,本文回顾性地介绍了升高高密度脂蛋白的药物及其进展,包括临床及临床前期药物及其作用机制。

关键词: 高密度脂蛋白, 动脉粥样硬化, 心血管疾病, 载脂蛋白, 胆固醇酯转运蛋白, 过氧化体增殖物激活型受体, 脂蛋白脂酶

Abstract: Atherosclerosis (AS) is pathologically important basis of many kinds of coronary atherosclerosis disease (CAD).It can be substantially protected by raising high-density lipoprotein (HDL).In view of mechanism, drugs for raising HDL include:cholesterol ester transfer protein inhibitors, peroxisomal proliferator-activated receptor agonists, liver X-activated receptor agonists, farnesoid X receptor antagonists or agonists, lipoprotein lipase activators, niacin, and phenytoin and lecin:cholesterol acyltransferase activators, etc.This review aimed to the progress of drugs for regulating highdensity lipoprotein and their mechanism, in view of clinical and preclinical aspects.

Key words: high-density lipoprotein(HDL), atherosclerosis(AS), coronary atherosclerosis disease (CAD), apolipoprotein, cholesterol ester transfer protein(CETP), peroxisomal proliferator-activated receptor (PPAR), lipoprotein lipase(LPL) 9129

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