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中国临床药理学与治疗学 ›› 2004, Vol. 9 ›› Issue (8): 859-862.

• 综述 • 上一篇    下一篇

儿童生长发育对药物作用的影响及意义

鞠瑞秀 综述, 王慎田 审校   

  1. 潍坊医学院附属青州医院药剂科, 青州262500, 山东
  • 收稿日期:2004-03-15 修回日期:2004-05-17 出版日期:2004-08-26 发布日期:2020-11-20
  • 通讯作者: 鞠瑞秀,男,副主任药师,主要从事临床药理学研究。Tel:0536-3276898 E-mail:qzwst@hotmail.com

Effects and significance of growth and development on drug metabolism in infants and children

JU Rui-Xiu, WANG Shen-Tian   

  1. Affiliated Qingzhou Hospital of Weifang Medical College, Qingzhou 262500, Shandong, China
  • Received:2004-03-15 Revised:2004-05-17 Online:2004-08-26 Published:2020-11-20

摘要: 儿童用药不同于成人,随着年龄增长身体的发育会影响药物的吸收、分布、代谢及清除等许多方面,从而影响药物的药代动力学。儿童的用药量及用药间隔随年龄增长而有所变化,临床上儿童用药应当制订与年龄相适应的最佳方案,而不是简单的按体重或年龄给药。

关键词: 儿童, 生长发育, 药代动力学, 药物代谢

Abstract: Infants and children are far from adults in terms of medications.The growth and developmental changes profoundly affect the absorption, distribution and metabolism of drugs and the response to medications.The dosage and interval of drugs change along with growth and development, so it is needed those age-dependent adjustments in infants and children.

Key words: children, growth and development, drug metabolism, pharmacodynamics

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