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中国临床药理学与治疗学 ›› 2004, Vol. 9 ›› Issue (8): 932-934.

• 研究原著 • 上一篇    下一篇

国产那格列奈片对2型糖尿病疗效的临床评价

夏礼斌, 陆美琴, 张斌华, 张安素, 陈月平, 华强, 冒国光1   

  1. 皖南医学院弋矶山医院内分泌科, 1国家药品临床研究基地, 芜湖241001, 安徽
  • 收稿日期:2004-07-22 修回日期:2004-07-25 出版日期:2004-08-26 发布日期:2020-11-20
  • 通讯作者: 夏礼斌,男,硕士,主治医师,研究方向:内分泌与免疫药理学。Tel:0553-5739315 E-mail:xialibin220@yahoo.com.cn

Clinical evaluation on efficacy of domestic nateglinide tablet in patients with type 2 diabetes mellitus

XIA Li-Bin, LU Mei-Qin, ZHANG Bin-Hua, ZHANG An-Su, CHEN Yue-Ping, HUA Qiang, MAO Guo-Guang1   

  1. Department of Endocrinology, 1National Drug Clinical Research Base, YijishanHospital, Wannan Medical College, Wuhu 241001, Anhui, China
  • Received:2004-07-22 Revised:2004-07-25 Online:2004-08-26 Published:2020-11-20

摘要: 目的: 评价国产那格列奈片治疗2 型糖尿病的疗效。方法: 46例2型糖尿病患者随机分入那格列奈组和瑞格列奈组,以瑞格列奈作阳性对照,检测空腹血糖及糖化血红蛋白(HbA1C)。结果: 两组治疗后空腹指尖及静脉血糖、糖化血红蛋白均有所下降,治疗8 周后瑞格列奈组空腹指尖血糖改善值优于那格列奈组。结论: 那格列奈片能改善2 型糖尿病患者的糖代谢,是一种安全有效的降糖药物。

关键词: 那格列奈, 瑞格列奈, 2 型糖尿病, 空腹血糖, 糖化血红蛋白

Abstract: AIM: To evaluate the efficacy of domestic nateglinide tablet with the treatment of patients with type 2 diabetes mellitus (T2DM).METHODS: Forty-six patients of T2DM were included in this study.The twentythree patients in nateglinide group took nateglinide tablet, and another twenty-three patients in the repaglinide group took repaglinide tablet.The changes of both fasting blood glucose and hemoglobin A1C(HbA1C)levels were assayed. RESULTS: After the treatment of 12 weeks, the levels of fasting blood glucose and HbA1C decreased significantly (P<0.01).After 8th weeks, the levels of fasting blood glucose of repaglinide group on finger-tip decreased significantly than those of the nateglinide group.CONCLUSION: Domestic nateglinide, as an effective and safe agent, can improve the glycometabolism in treating T2DM.

Key words: nateglinide tablet, repaglinide tablet, hemoglobin A1C, type 2 diabetes mellitus, fasting blood glucose

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