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中国临床药理学与治疗学 ›› 2004, Vol. 9 ›› Issue (9): 1023-1025.

• 研究原著 • 上一篇    下一篇

血塞通滴丸治疗中风(脉络瘀阻证)的临床研究

赵映前, 张方健, 巴元明, 胡有志, 向楠, 冯德勋, 石杰   

  1. 湖北中医学院附属医院内科, 武汉430061, 湖北
  • 收稿日期:2004-06-23 修回日期:2004-08-02 出版日期:2004-09-26 发布日期:2020-11-23
  • 通讯作者: 赵映前, 男, 博士, 教授, 博士生导师, 研究方向:内科疾病的中医治疗。Tel:027-88929115 E-mail:hbzyfyky @public.wh. hb. cn

Clinical efficacy and safety of xuesetong pill in the treatment of patients with stroke

ZHAO Yin-Qian, ZHANG Fang-Jian, BA Yuan-Ming, HU You-Zhi, XIANG Nan, FENG De-Xun, SHI Jie   

  1. Department of Internal Medicine, Affliated Hospital of Hubei Traditional Chinese Medicine College, Wuhan 430061, Hubei, China
  • Received:2004-06-23 Revised:2004-08-02 Online:2004-09-26 Published:2020-11-23

摘要: 目的: 评价血塞通滴丸治疗中风病(脉络瘀阻证)的临床疗效与安全性。方法: 以血塞通片为对照, 进行随机、双盲双模拟、阳性药平行对照、多中心临床试验。结果: 血塞通滴丸治疗中风患者的证候总有效率为90. 3 %, 中风病总有效率为91. 9 %。在治疗2 、3 、4 周后对中医证候、中医证候总积分、中风病、和中风病总积分的改善优于对照组(P<0. 05)。 血塞通滴丸的起效时间(13. 16±4. 90 d)明显优于对照组(19. 10±6. 78 d, P<0. 01)。对血液流变学的各项指标疗效均不明显, 两组无显著性差异(P > 0. 05)。两组未见明显不良反应, 一般体检项目, 血、尿、粪常规, 肝、肾功能试验前检查正常者试验后亦无异常。结论: 血塞通滴丸治疗中风病(脉络瘀阻证)具有安全、有效、起效快等特点。

关键词: 血塞通滴丸, 中风病, 药物不良反应

Abstract: AIM: To observe the clinical efficacy and safety of xuesetong pill in the treatment of patients with stroke.METHODS: Xuesetong pill was observed in the paralleled-control, double-blind, and double-simulated clinical trail.RESULTS: Xuesetong pill significantly improved the symptom of patient with stroke. Its total effective rate to the symptom was up to 90. 3 %.After the treatment of xuesetong pill for 2, 3, and 4 weeks, the improvement of traditional medicine symptom, total score of traditional medicine symptom, stroke and total score of stroke were superior to those in the control group (P<0. 05).Its latent period of efficacy was 13. 16±4. 90 days, which was obviously superior to that in the control group (19. 10±6. 78 days)(P<0. 01).No serious side effect was found in the two groups.CONCLUSION: Xuesetong pill has a characteristic of safe, effective, and fast in the treatment of patients with stroke.

Key words: xuesetong pill, stroke, adverse drug effects, clinical trials

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