孕酮和孕烯醇酮硫酸盐对东莨菪碱引起的小鼠记忆损伤的保护作用

中国临床药理学与治疗学 ›› 2004, Vol. 9 ›› Issue (9): 1030-1032.

孕酮和孕烯醇酮硫酸盐对东莨菪碱引起的小鼠记忆损伤的保护作用

王丹, 于榕, 鲁映青, 姚明辉

复旦大学上海医学院药理学系, 上海200032

收稿日期:2004-04-02 接受日期:2004-07-22 出版日期:2004-09-26 发布日期:2020-11-23

Protective effects of progesterone and pregnenolone sulfate on memory impairment mice induced by scopolamine

WANG Dan, YU Rong, LU Ying-Qing, YAO Ming-Hui

Department of Pharmacology, Shanghai Medical College, Fudan University, Shanghai 200032, China

Received:2004-04-02 Accepted:2004-07-22 Online:2004-09-26 Published:2020-11-23
Contact: YU Rong, male, Ph. D. , associate professor, engaged in neuropharmacology. Tel:021-54237228 E-mail:ryu @shmu. edu. cn
About author:WANG Dan, female, graduate student of Master Degree, engaged in neuropharmacology. Tel:021-64165314 E-mail:022101058 @fudan. edu. cn
Supported by:
Project supported by Natural Science Foundation of Shanghai (№02ZB14007)

摘要/Abstract

摘要： 目的: 观察孕酮和孕烯醇酮硫酸盐对东莨菪碱引起的小鼠记忆损伤的保护作用。方法: 用东莨菪碱造成小鼠记忆损伤的模型, 应用被动避暗试验测定潜伏期以评价记忆成绩。结果: 小鼠给予东莨菪碱(1 mg·kg^-1, ip) 后, 其潜伏期显著减少, 表明造成了明显的记忆损伤。孕酮(1, 10 mg·kg^-1, sc) 和孕烯醇酮硫酸盐(1 mg·kg^-1, sc) 均可以在被动避暗试验中减轻东莨菪碱引起的记忆损伤。结论: 孕酮和孕烯醇酮硫酸盐可改善记忆损伤。

关键词: 孕酮, 孕烯醇酮硫酸盐, 东莨菪碱, 记忆, 被动避暗试验

Abstract: AIM: To investigate the protective effects of progesterone and pregnenolone sulfate on memory impairment mice induced by scopolamine.METHODS: Pharmacological model of amnesia inmice was induced by scopolamine. Memory result was evaluated by the stepthrough latency in the passive-avoidance task.RESULTS: Animals displayed marked decrease in the stepthrough latency after administration (scopolamine 1 mg·kg^-1, ip). Progesterone (1 mg·kg^-1, 10 mg·kg^-1, sc) and pregnenolone sulfate (1 mg·kg^-1, sc ) significantly decreased performance of animals in the passiveavoidance task.CONCLUSION: Progesterone and pregnenolone sulfate can ameliorate the memory deficit.

Key words: progesterone, pregnenolone sulfate, scopolamine, memory, passive-avoidance task

中图分类号:

R964

王丹, 于榕, 鲁映青, 姚明辉. 孕酮和孕烯醇酮硫酸盐对东莨菪碱引起的小鼠记忆损伤的保护作用[J]. 中国临床药理学与治疗学, 2004, 9(9): 1030-1032.

WANG Dan, YU Rong, LU Ying-Qing, YAO Ming-Hui. Protective effects of progesterone and pregnenolone sulfate on memory impairment mice induced by scopolamine[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2004, 9(9): 1030-1032.

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