人 UrotensinⅡ在心血管系统中的生物学效应

中国临床药理学与治疗学 ›› 2005, Vol. 10 ›› Issue (11): 1210-1214.

人 UrotensinⅡ在心血管系统中的生物学效应

丁波, 高杉, 陈志武

安徽医科大学药理学教研室,合肥 230032,安徽

收稿日期:2005-08-15 修回日期:2005-10-08 出版日期:2005-11-26 发布日期:2020-11-12
作者简介:丁波,硕士研究生,研究方向:心血管药理。Tel:(0) 13866738835 E-mail:lilymiffy2005@hotmail.com
基金资助:
安徽省海外留学人才资金资助(No2005Z031)

Biological actions of human urotensin II on cardiovascularsystem

DING Bo, GAO Shan, CHEN Zhi-wu

Department of Pharmacology,Anhui Medical University,Hefei 230032,Anhui,China

Received:2005-08-15 Revised:2005-10-08 Online:2005-11-26 Published:2020-11-12

摘要/Abstract

摘要： UrotensinII最早是从鱼尾部下垂体中分离出的神经环肽,随后在一种欧洲绿蛙Ranaridibunda的脑中鉴别出来和从人体基因组中克隆出来。人Uro-tensinII(humanurotensinII,hUII)有11个氨基酸残基组成,主要分布于心血管和神经系统。作为UT受体的一种内源性配体,hUII有广泛的生物学效应,如收缩和舒张血管,促进心肌细胞增殖,调节心功能,并在冠心病、心功能衰竭等某些心血管疾病的病理过程中起着重要的作用。本文就hUII在心血管系统方面的生物学效应作一简要的综述。

关键词: 人UrotensinII, 心血管系统, UT受体, 生物学效应

Abstract: Urotensin II(U-II),a cyclic peptide has been initially identified as a neuropeptide of teleost fish.Subsequently,U-II has been characterized in the brain of the Europeangreen frog and has also been cloned from the human genome.Human U-II(human U-II,hU-II),composed of 11 amino acid residues is rich in cardiovas-cularand nervous system.As an endogenous ligand forUT receptor,hU-II exerts a broad spectrum of biological actions,such as vasoconstriction and vasorelaxation,fa-cilitating proliferation of cardiac cells,regulating the car-diac function and playing an important role in pathogene-sis of some cardiovasculardiseases such as coronary heart disease and cardiac failure.The effects of hU-II on card-iovascularsystem were briefly reviewed as follows.

Key words: human urotensinII, cardiovascularsys-tem, UT receptor, biological actions

中图分类号:

R972

丁波, 高杉, 陈志武. 人 UrotensinⅡ在心血管系统中的生物学效应[J]. 中国临床药理学与治疗学, 2005, 10(11): 1210-1214.

DING Bo, GAO Shan, CHEN Zhi-wu. Biological actions of human urotensin II on cardiovascularsystem[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2005, 10(11): 1210-1214.

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