关键词: 抗内毒素多肽, 内毒素, 内毒素休克

Abstract: AIM: To observe the effects of antiendotoxin polypeptide on the arterial blood pressure of endotoxin-shocked rabbits.METHODS: The changes of mean arterial blood pressure (MABP), pulse pressure, LPS in plasma, alanine aminotransferase (Alt), MB isoenzyme of creatine kinase (CK-MB), creatinine (Cr) of the endotoxic shocked rabbits at different time points were investigated when BNEP (10 g·L^-1) were injected in vein just after lipopolysaccharide (LPS) 500 mg·L^-1 were injected.And the mortality at the 8th hour had been observed.RESULTS: The decreasing of MABP and pulse pressure of rabbits treated with BNEP were partially blocked.After 6th hour-treatment with BNEP, the MABP and pulse pressure were back to more than 80% of those before injection of LPS.The concentrations of LPS in plasma at different time points were decreased significantly.The pulse pressure at the 2nd, 4th and 6th hour, CKMB at the 4th and 6th hour, the mortality at the 8th hour were significantly lower than that in the LPS group.But there were no significantly difference of the change of ALT in the two groups.CONCLUSION: BNEP has a high capacity of neutralizing LPS and positive effects on the amelioration and the recovery of the functions of kidney, liver and cardiovascular system of endotoxic shocked rabbits.So it is potential in the accessorial treatment of patients with severe infection.

Key words: antiendotoxin polypeptide, LPS, endotoxic shock