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中国临床药理学与治疗学 ›› 2005, Vol. 10 ›› Issue (8): 898-902.

• 研究原著 • 上一篇    下一篇

人参皂苷Rg1脂质体对东莨菪碱诱导大鼠学习记忆障碍的改善及其作用机制

陈新梅, 朱家壁   

  1. 中国药科大学药物制剂研究所, 南京 210009, 江苏
  • 收稿日期:2005-06-23 修回日期:2005-07-27 发布日期:2020-11-22
  • 通讯作者: 朱家壁,男,教授,博士生导师,研究方向:药物新剂型及吸收动力学。Tel:025-85338217 E-mail:zjbbox02@vip.163.com
  • 作者简介:陈新梅,女,博士研究生,研究方向:药物新剂型及吸收动力学。Tel:025-85338217 E-mail:xinmeichen@126.com

Effects and mechanisms of ginsenoside Rg1 on learning and memory impairment induced by scopolamine hydrobromide

CHEN Xin-mei, ZHU Jia-bi   

  1. Institute of Pharmaceutical, China Pharmaceutical University, Nanjing 210009, Jiangsu, China
  • Received:2005-06-23 Revised:2005-07-27 Published:2020-11-22

摘要: 目的: 观察人参皂苷Rg1脂质体(Rg1-L)对东莨菪碱诱导大鼠学习记忆障碍的改善,并探讨其相关机制。方法: 制备东莨菪碱诱导大鼠学习记忆障碍模型,采用Y型迷宫评价Rg1-L对模型大鼠学习记忆的影响,并测定大鼠大脑皮质中乙酰胆碱酯酶活性。结果: Rg1-L可以显著改善模型大鼠学习记忆功能,同时抑制大脑皮质中乙酰胆碱酯酶活性。结论: Rg1-L对东莨菪碱诱导大鼠学习记忆障碍模型大鼠的学习记忆功能有显著的改善作用,其机制可能与抑制大脑皮质中乙酰胆碱酯酶活性、提高人参皂苷Rg1生物利用度有关。

关键词: 阿尔茨海默病, 学习记忆障碍, 乙酰胆碱酯酶, 人参皂苷Rg1 脂质体

Abstract: AIM: To study the protective effects of ginsenosides Rg1 liposome (Rg1-L) on learning and memory impaiment induced by scopolamine hydrobromide in rats, and discuss the relevant mechanisms.METHODS: AD model was made by scopolamine hydrobromide.Ymaze was used to detect the learning and memory abilities.The active of acetylcholinesterase (AchE) in the brain of rats was measured.RESULTS: Rg1-L obviously improved the learning andmemory abilities of AD rats and restrained the activity of AchE.CONCLUSION: Rg1-L improves the learning and memory abilities of AD.The relevant mechanisms may be related to restraining the activity of AchE, improving the lipophilic activity of Rg1 by liposome and bio avalbility.

Key words: Alzheimer's disease, learning and memory impairment, acetylcholinesterase, liposome

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