猪牙皂正丁醇部分对过敏性鼻炎的影响

中国临床药理学与治疗学 ›› 2005, Vol. 10 ›› Issue (8): 925-928.

猪牙皂正丁醇部分对过敏性鼻炎的影响

夏玉凤¹, 戴岳, 符麟军

中国药科大学中药药理教研室, ¹中药分析教研室, 南京 210038, 江苏

收稿日期:2005-06-06 修回日期:2005-07-08 发布日期:2020-11-22
通讯作者: 戴岳,教授,博士生导师,研究方向:中药免疫药理学。Tel:025-85391258 E-mail:yuedaicpu@hotmail.com
作者简介:夏玉凤,女,副研究员,硕士,研究方向:中药活性成分及质量分析。

Inhibition of allergic rhinitis by n-butanol fraction from anomalous fruits of Gleditsia sinensis

XIA Yu-feng¹, DAI Yue, FU Lin-jun

Department of Pharmacology of Chinese Materia Medica, ¹Department of Chinese Materia Medica Analysis, China Pharmaceutical University, Nanjing 210038, Jiangsu, China

Received:2005-06-06 Revised:2005-07-08 Published:2020-11-22

摘要/Abstract

摘要： 目的: 观察猪牙皂正丁醇部分(NBGS)对过敏性鼻炎的治疗作用,探讨其可能的作用机制。方法: 以卵白蛋白致敏小鼠或大鼠,观察药物对小鼠鼻炎症状、鼻腔敏感性和血清一氧化氮水平的影响,以及对大鼠鼻腔白细胞渗出的作用。结果: NBGS(100,200mg·kg^-1)灌胃给药,明显减少小鼠的擦鼻次数,降低鼻粘膜对组胺的敏感性和血清一氧化氮水平,抑制大鼠鼻腔嗜酸性粒细胞渗出,但对单核细胞和嗜中性粒细胞渗出无明显影响。结论: NBGS抑制过敏性鼻炎,其作用可能与降低鼻粘膜的高反应性及嗜酸性粒细胞浸润有关。

关键词: 猪牙皂, 过敏性鼻炎, 高反应性, 一氧化氮, 白细胞浸润

Abstract: AIM: To investigate the effects of the Nbutanol fraction from the anomalous fruits of Gleditsia sinensis (NBGS)on allergic rhinitis, and to explore the underlying mechanism of action.METHODS: In sensitized mice with ovalbumin, effects of NBGS on rhinitis symptoms, nasal histamine responsiveness and serum levels of nitric oxide were studied.In sensitized rats, effect of NBGS on the numbers of differential leukocytes in nasal cavity lavage fluid was observed.RESULTS: NBGS (100, 200 mg·kg^-1, p.o.)effectively reduced nasal wiping times, nasal hyperresponsiveness and serum levels of nitric oxide in sensitized mice.NBGS also restrained eosinophil effusion of nasal cavity in sensitized rats, but it did not affect the effusion of monocytes and neutrophils.CONCLUSION: NBGS is effective in alleviating the nasal symptoms of allergic rhinitis, which is probably contributed by lowing nasal hyperresponsiveness and eosinophil infiltration.

Key words: Gleditsia sinensis, allergic rhinitis, hyperresponsiveness, nitric oxide, leukocyte infiltration

中图分类号:

R765.21

夏玉凤, 戴岳, 符麟军. 猪牙皂正丁醇部分对过敏性鼻炎的影响[J]. 中国临床药理学与治疗学, 2005, 10(8): 925-928.

XIA Yu-feng, DAI Yue, FU Lin-jun. Inhibition of allergic rhinitis by n-butanol fraction from anomalous fruits of Gleditsia sinensis[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2005, 10(8): 925-928.

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