欢迎访问《中国临床药理学与治疗学》杂志官方网站,今天是

中国临床药理学与治疗学 ›› 2005, Vol. 10 ›› Issue (8): 940-942.

• 研究原著 • 上一篇    下一篇

大豆异黄酮活性组分对阿尔茨海默病小鼠抗氧化作用的研究

杨红, 陈伟强1, 罗少洪, 金桂芳, 潘伟   

  1. 广东药学院生物化学教研室, 1病理生理教研室, 广州 510224, 广东
  • 收稿日期:2005-04-04 修回日期:2005-05-28 发布日期:2020-11-22
  • 通讯作者: 杨红,女,硕士,副教授,硕士生导师,研究方向:生化技术与生物制药。Tel:020-39352067 E-mail:yanghong@gdpu.edu.cn
  • 基金资助:
    广东省科技厅计划项目(No2004B30101001);广东省中医药局科研项目(No103079)

Antioxidative effects of soybean isoflavone active-extracts in AD mice

YANG Hong, CHEN Wei-qiang1, LUO Shao-hong, JING Gui-fang, PAN Wei   

  1. Department of Biochemistry, 1Department of Pathophysiology, Guangdong College of Pharmacy, Guangzhou 510224, Guangdong, China
  • Received:2005-04-04 Revised:2005-05-28 Published:2020-11-22

摘要: 目的: 探讨大豆异黄酮活性组分对阿尔茨海默病(Alzheimer'sdisease,AD)小鼠的抗氧化作用。方法: 取10月龄的小鼠,以D-半乳糖和三氯化铝复制AD模型小鼠,用本实验室制备的大豆异黄酮活性组分灌胃15d后,眼球取血,测定血清中超氧化物歧化酶(SOD)、乳酸脱氢酶(LDH)和丙二醛(MDA)的含量,观察脑内海马组织切片神经元细胞的形态改变。结果: 与模型组小鼠相比,实验组小鼠血清SOD活力显著提高(P<0.01)、血清LDH含量显著升高(P<0.05)、血清MDA含量明显降低(P<0.01),海马区神经元细胞数量也显著增多,形态改善。结论: 异黄酮活性组分能有效地改善衰老AD小鼠的抗氧化系统的功能。

关键词: 大豆异黄酮活性组分, AD 小鼠, 抗氧化, 海马区, 神经元细胞

Abstract: AIM: To investigate the antioxidative effect of in Alzheimer's Disease mice.METHODS: AD model mice were made by D-galactose and aluminum chloride, and administered with the soybean isoflavone active-extracts for 15 days.The activities of SOD and LDH, and the levels of MAD were measured in serum. The morphology and quantity of nerve cells were observed in hippocampus tissue.RESULTS: The activities of SOD and LDH significantly increased in the ISO groups(P < 0.01), the MAD levels obviously decreased in the model group(P <0.01), the quantity of the nerve cells increased, and its morphology was better than that in the model group.CONCLUSION: The soybean isoflavone active-extracts can improve the antioxidative functions in AD mouses.

Key words: soybean isoflavone active-extracts, AD mice, antioxidative, hippocampus, nerve cells

中图分类号: