高血压病患者血压水平与脑血管并发症发生率的关系

中国临床药理学与治疗学 ›› 2005, Vol. 10 ›› Issue (9): 1030-1032.

高血压病患者血压水平与脑血管并发症发生率的关系

蔡平, 洪华山, 王一波

福建医科大学附属协和医院心内科, 福州 350001, 福建

收稿日期:2005-04-15 修回日期:2005-05-27 发布日期:2020-11-22
通讯作者: 洪华山,男,博士,主任医师,硕士生导师,研究方向:心力衰竭的基础和临床研究。Tel:0591-83357896-8475 E-mail:honghuashan@hotmail.com
作者简介:蔡平,女,硕士,副主任医师,研究方向:高血压病的基础和临床研究。Tel:(0)13609560920 E-mail:caiping@medmail.com.cn

Relationship between different level of blood pressure and incidence of cerebral complication in patients with essential hypertension

CAI Ping, HONG Hua-shan, WANG Yi-bo

Department of Cardiology, Affiliated Union Hospital, Fujian Medical University, Fuzhou 350001, Fujian, China

Received:2005-04-15 Revised:2005-05-27 Published:2020-11-22

摘要/Abstract

摘要： 目的: 探讨不同血压水平与高血压病脑血管并发症发生率的关系。方法: 回顾性调查近5 年住我院未治疗高血压病患者696 例(男387 例, 女309例), 按不同收缩压、舒张压和脉压水平进行分组, 分析不同收缩压、舒张压及脉压水平与脑血管并发症发生率的关系。结果: 脑血管并发症的发生率与收缩压、舒张压和脉压有关(P <0.05), 其影响顺序依次为:脉压>收缩压>舒张压。结论: 高血压病患者脑血管并发症发生率与收缩压、舒张压和脉压有关, 但脉压起着更重要的作用。

关键词: 高血压病, 收缩压, 舒张压, 脉压, 脑并发症

Abstract: AIM: To investigate the relationship between different level of blood pressure and the incidence of cerebral complication in patients with essential hypertensive.METHODS: 696 cases of untreated primary hypertensive patients (387 male and 309 female) were divided into different groups according to the level of systolic blood pressure (SBP), diastolic blood pressure (DBP) and pulse pressure (PP).The relationship between different level of SBP, DBP and PP was analyzed.RESULTS: The incidence of cerebral complication were positively correlated to SBP, DBP and PP (all P < 0.05).The impact ranking was PP >SBP >DBP.CONCLUSION: The cerebral complication in essential hypertension is correlated to SBP, DBP and PP.However, PP plays the most important role among the different parameters of blood pressure in the pathogenesis of the cerebral complication.

Key words: hypertension, systolic blood pressure, diastolic blood pressure, pulse pressure, cerebral complication

中图分类号:

R544.1

蔡平, 洪华山, 王一波. 高血压病患者血压水平与脑血管并发症发生率的关系[J]. 中国临床药理学与治疗学, 2005, 10(9): 1030-1032.

CAI Ping, HONG Hua-shan, WANG Yi-bo. Relationship between different level of blood pressure and incidence of cerebral complication in patients with essential hypertension[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2005, 10(9): 1030-1032.

参考文献

1 Mac MM, Sheahan N, Malone JF.Relation between aortic atherosclerosis and blood pressure[J].Lancet, 1994;343: 1107
2 吴兆苏, 姚崇华, 赵冬, 吴桂贤, 王薇, 刘静, 等.中国多省市心血管病趋势及决定因素的人群监测(中国MONICA方案)[J].中华心血管病杂志, 1998;26:85-8
3 Lindenstrom E, Boysen G, Nyboe J.Influence of systolic and diastolic blood pressure on stroke risk:a prospective observational study[J].Am J Epidemiol, 1995;142:1279-90
4 Benetos A, Thomas F, Bean K, Gautier S, Smulyan H, Guize L. Prognostic value of systolic and diastolic blood pressure in treated hypertensive men[J].Arch InternMed, 2002;162:577-81
5 Liu L, Wang JG, Goog L, Liu G, Staessen JA.Comparision of active treatment and placebo in older chinese patients with isolated systolic hypertension[J].J Hypertens, 1998;16:1823-9
6 中国老年高血压临床试验组.中国老年收缩期高血压临床试验总结报告[J].中华心血管病杂志, 1998;26:329-33
7 SHEP Cooperative Research Group.Prevention of stroke by antihypertensive drug treatment in older persons with isoleted systolic hypertension.final results of the systolic hypertension in the elderly program(SHEP)[J].JAMA, 1991;26:3244-55
8 Domanski MJ, Davis BR, Pfeffer MA, Kastantin M, Mitchell GF. Isolated systolic hypertension prognostic information provided by pulse pressure[J].Hypertension, 1999;34:375-80
9 Verdecchia P, Schillaci G, Reboldi G.Different prognostic impact of 24-hour mean blood pressure and pulse pressure on stroke and coronary artery disease in essential hypertention[J]. Circulation, 2001;103:2579-84
10 Kario K, Ishikawa J, Eguchi K, Morinari M, Hoshide S, Ishikawa S, et al.Sleep pulse pressure and awake mean pressure as independent predictors for stroke in older hypertensive patients[J].Am J Hypertens, 2004;17:439-45
11 吴桂贤, 吴兆苏, 刘静, 曾哲淳, 王文化, 秦兰萍, 等.人群脉压分布特征的研究[J].中华心血管病杂志, 2001;29:436-40
12 吴桂贤, 吴兆苏, 秦兰萍, 刘静, 曾哲淳, 王文化, 等.心脑血管病与脉压水平的研究[J].北京医学, 2001;23:202-4
13 王宏宇, 张维忠, 龚兰生, 胡大一.高血压合并动脉粥样硬化与大动脉缓冲功能关系的研究[J].中华心血管病杂志, 2001;29:206-9

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