术前口服依他昔布对妇科手术后病人自控镇痛的影响

中国临床药理学与治疗学 ›› 2005, Vol. 10 ›› Issue (9): 984-987.

术前口服依他昔布对妇科手术后病人自控镇痛的影响

刘薇, Loo CC¹, 秦晓涛¹, 黄宇光

中国医学科学院中国协和医科大学北京协和医院麻醉科, 北京 100730;
¹Anesthesia Department (O&G), Singapore KK Women's and Children's Hospital, Singapore 229899, Singapore

收稿日期:2005-08-12 修回日期:2005-08-16 发布日期:2020-11-22
通讯作者: 刘薇,女,医学博士,主治医生,主要研究方向:妇产科手术麻醉与镇痛。Tel:010-65295621 E-mail:vivipumc@yahoo.com.cn

Effect of etoricoxib on postoperative patient-controlled analgesia in major gynecological operation

LIU Wei, Loo CC¹, QIN Xiao-tao¹, HUANG Yu-guang

Department of Anesthesiology, Peking Union Medical College Hospital, Beijing 100730, China;
¹Anesthesia Department (O&G), Singapore KK Women's and Children's Hospital, Singapore 229899, Singapore;

Received:2005-08-12 Revised:2005-08-16 Published:2020-11-22

摘要/Abstract

摘要： 目的: 观察妇科开腹手术患者术前给予依他昔布120 mg 对术后自控镇痛(PCA) 吗啡用量的影响及其副作用。方法: 随机选取全麻下接受妇科开腹全子宫(双附件) 切除患者40 例, 术前分别给予安慰剂或依他昔布120 mg 口服。在手术后观察24 h 患者PCA 吗啡用量, 同时记录患者的疼痛评分和满意度评分, 并观察不良反应。结果: 术后PCA 吗啡24h 消耗量在依他昔布组为9.4±7.6 mg, 显著低于安慰剂组15.7±8.9 mg。两组患者24 h 内对PCA 的按压次数依他昔布组也低于安慰剂组(P <0.05)。其中术后3、6、8 和12 h PCA 吗啡消耗量在两组间无显著差异。两组患者术后24 h 疼痛评分和对镇痛治疗的满意度也无差异。两组患者不良反应的发生率亦无差别。结论: 在妇科开腹手术患者术前应用依他昔布120 mg 可使患者术后PCA 吗啡消耗量降低, 且在术后12 h 后下降明显。未发现与依他昔布应用相关的副作用。

关键词: 依他昔布, 病人自控镇痛, COX-2 抑制剂, 吗啡

Abstract: AIM: To observe the effect of preemptive etoricoxib on postoperative PCA in the major gynecological surgery.METHODS: 40 patients who underwent major gynecological surgery were selected randomly to receive placebo or etoricoxib 120 mg before surgery.The PCA morphine consumption in 24 hours was recorded and patients'satisfaction was evaluated by 0-10 scores.At the same time, side effects were also recorded.RESULTS: Postoperative 24 hours PCA morphine consumption in etoricoxib group was 9.4±7.6 mg, and it was significant lower than which in placebo group 15.7±8.9 mg.The overall PCA attempts was also lower in etoricoxib group than in placebo group(P <0.05).The first 6 hours and first 12 hours morphine consumption of PCA had no significant difference between two groups.There were no significant differences of patients'satisfaction and side effects rates between two groups.CONCLUSION: The preemptive etoricoxib 120mg in major gynecological surgery may decrease postoperative PCA morphine consumption, especially 12 hours after operation.Patients'satisfaction score have no improvements and no significant side effects caused by etoricoxib were found.

Key words: etoricoxib, COX-2 inhibitor, patientcontrolled analgesia, morphine

中图分类号:

R614

刘薇, Loo CC, 秦晓涛, 黄宇光. 术前口服依他昔布对妇科手术后病人自控镇痛的影响[J]. 中国临床药理学与治疗学, 2005, 10(9): 984-987.

LIU Wei, Loo CC, QIN Xiao-tao, HUANG Yu-guang. Effect of etoricoxib on postoperative patient-controlled analgesia in major gynecological operation[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2005, 10(9): 984-987.

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