埃索美拉唑治疗胃食管反流病的系统评价

中国临床药理学与治疗学 ›› 2006, Vol. 11 ›› Issue (10): 1154-1159.

埃索美拉唑治疗胃食管反流病的系统评价

钟利春, 贾红¹, 李昌平, 邹义君

泸州医学院附属医院消化内科, 泸州 646000, 四川;
¹泸州医学院公共卫生学院, 泸州 646000, 四川

收稿日期:2006-04-26 修回日期:2006-06-08 出版日期:2006-10-26 发布日期:2020-11-05
作者简介:钟利春, 女, 医师, 在读研究生, 研究方向为消化循证。Tel:13982761136 E-mail:zhonglichunj@163.com

Esomeprazole for gastroesephageal reflux disease:a systematic review

ZHONG Li-chun, JIA Hong¹, LI Chang-ping, ZHOU Yi-jun

Department of Gastroenterology , Affiliated Hospital of Luzhou Medical College, Luzhou 646000 , Sichuan, China;
¹Department of Public Health, Luzhou Medical College, Luzhou 646000 , Sichuan, China

Received:2006-04-26 Revised:2006-06-08 Online:2006-10-26 Published:2020-11-05

摘要/Abstract

摘要： 目的评价埃索美拉唑与其它质子泵抑制剂(PPI) 比较治疗胃食管反流病的疗效。方法文献检索并收集埃索美拉唑与其它PPI 相比较的随机对照试验文献, 按Cochrane 协作网提供的方法对纳入文献进行质量评价。结果共纳入14 个随机对照研究(RCT) 。对于非糜烂性食管炎埃索美拉唑与潘索拉唑比较在6 个月后症状缓解率差异有统计学意义。对于糜烂性食管炎, 埃索美拉唑与其他PPI 比较均有统计学意义。结论对于非糜烂性食管炎, 埃索美拉唑比潘索拉唑疗效好;对于糜烂性食管炎, 埃索美拉唑比其他PPI 疗效好。

关键词: 埃索美拉唑, 胃食管反流病, 系统评价, Meta 分析

Abstract: AIM: To evaluate the efficacy of esomeprazole in the treatment of gastroesephageal reflux disease(GERD) when compared to the other PPI.METHODS: We were searching RCT researchers contacted.The quality evaluation of studies and data analysis were conducted by the methods of the Cochrane Collaboration.RESULTS: Fourteen RCTs met the inclusion criteria.In patients with NERD symptom relief rate esomeprazole had significant effect when compared with pantoprazole.In patients with EE symptom relief rate esomeprazole had significant effect comparing with the other PPI.CONCLUSION: Esomeprazole was better than pantoprazole in patients with NERD symptom relief rate.In patients with EE symptom relief rate esomeprazole was better than the other PPI.

Key words: esomeprazole, gastroesephageal reflux disease, systematic review, Meta-analysis

中图分类号:

R969

钟利春, 贾红, 李昌平, 邹义君. 埃索美拉唑治疗胃食管反流病的系统评价[J]. 中国临床药理学与治疗学, 2006, 11(10): 1154-1159.

ZHONG Li-chun, JIA Hong, LI Chang-ping, ZHOU Yi-jun. Esomeprazole for gastroesephageal reflux disease:a systematic review[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2006, 11(10): 1154-1159.

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