RT-Q医用生物膜的止血及生物相容性研究

中国临床药理学与治疗学 ›› 2006, Vol. 11 ›› Issue (12): 1345-1349.

RT-Q医用生物膜的止血及生物相容性研究

陈重华, 程薇波¹, 尹宗宁, 田娟, 陈国经²

四川大学华西药学院药理教研室,¹公共卫生学院毒理研究室, 成都 610041, 四川;
²成都博联医疗信息产业有限责任公司, 成都 610041, 四川

收稿日期:2006-05-30 修回日期:2006-07-28 出版日期:2006-12-26 发布日期:2020-11-06
作者简介:陈重华, 女, 硕士, 讲师, 研究方向:抗炎、免疫药理。Tel:13881996013 　E-mail:chenzhonghua-1@163.com;程薇波, 女, 硕士, 副教授, 研究方向:毒理病理学。Tel:028-85501503 　E-mail:marychong@126.com
基金资助:
国家863 计划资助课题(No2002AA326050)

Study of hemostatic effect and biocompatibility of RT-Q-remedial biomembrane

CHEN Zhong-hua, CHENG Wei-bo¹, YIN Zong-ning, TIAN Juan, CHEN Guo-jing²

West China School of Pharmacy,¹Public Health, SichuanUniversity, Chengdu 610041, Sichuan, China;
²Chengdu Bolian Medical Information Industry Co.Ltd, Chengdu 610041, Sichuan, China

Received:2006-05-30 Revised:2006-07-28 Online:2006-12-26 Published:2020-11-06

摘要/Abstract

摘要： 目的研究RT-Q 医用生物膜(以下简称RT-Q膜) 的术中局部止血作用及其生物相容性。方法通过比较RT-Q 膜、瞬康医用胶(以下简称瞬康胶) 、附加剂、阴性对照对大鼠颈外静脉切口出血时间和出血量的影响, 研究其术中止血效果;通过观察大鼠后肢肌肉切开用此膜后对伤口愈合、生物膜降解及周围组织是否有毒性影响等情况评价其生物相容性。结果与阴性对照组、附加剂组比较, RT-Q 膜组止血效果显著(P<0.01), 与瞬康医用胶组比较无统计学意义;RT-Q 膜对伤口愈合既无促进也无延迟性影响, 形成的膜于术后15 d 开始降解, 3 ~ 4 周完全吸收, 对周围组织无毒性影响。结论 RT-Q 医用生物膜的局部止血效果显著、且具有生物相容性。

关键词: RT-Q 膜, 局部止血, 生物相容性

Abstract: AIM: To investigate the hemostatic effect and biocompatibility of RT-Q-remedial biomembrane.METHODS: There were control, excipient, Shunkang and RT-Q grouPin topical bleeding experiment and control, excipient, and RT-Q grouPin topical biocompatibility experiment, in order to study the hemostatic effect on jugular vein of rat, and to observe the biodegradability and histocompatibility of RT-Q in muscle of rat legs.RESULTS: The hemostatic effect is significant compared with control grouPand excipient grouP(P<0.01), but there is no significant difference compared with Shunkang grouP(P>0.05).The biological evaluation for the biocompatibility is excellent.CONCLUSION: The significant hemostatic effect and good biocompatibility have been proved in topical bleeding of RT-Q.

Key words: RT-Q-biomembrane, topical stanch, biocompatibility

中图分类号:

R619+.1

陈重华, 程薇波, 尹宗宁, 田娟, 陈国经. RT-Q医用生物膜的止血及生物相容性研究[J]. 中国临床药理学与治疗学, 2006, 11(12): 1345-1349.

CHEN Zhong-hua, CHENG Wei-bo, YIN Zong-ning, TIAN Juan, CHEN Guo-jing. Study of hemostatic effect and biocompatibility of RT-Q-remedial biomembrane[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2006, 11(12): 1345-1349.