关键词: 灯盏花素, 异丙肾上腺素, 心肌肥大, 超级氧化物歧化酶

Abstract: AIM: To investigate effects of Breviscapin on isoproterenol- inducedmyocardial hypertrophy in mice.METHODS: Isoproterenol was given subcutaneously (3mg·kg^-1,5 days) to induce myocardial hypertrophy in mice.Therapy grouPwere given Breviscapin 30 minutes before ISO treatment.We investigated the cardiac weight index and the malonyldialdehyde (MDA) content,the activity of superoxide dismutase(SOD),Ca²⁺-Mg²⁺-ATPase in myocardium and aspartate aminotransferase (AST) in serum,Myocardiac morphological alteration was observed by micrography.RESULTS: In cardiac hypertrophy model group,HW/BW,LVW/BW (the ratio of whole heart weight to body weight and left ventricle weight to body weight),and cardiac MDA,serum AST content were increased,the activity of SOD and Ca^{2 +}-Mg²⁺-ATPase were decreased compared with control.Breviscapin improved all the above parameters significantly and improved the left ventricular tissue morphological alteration.CONCLUSION: Breviscapine possess protective effects against Isoproterenol induced myocardial hypertrophy in mice.This may be related to reducing the oxidative stress and improving energy metabolism.

Key words: Breviscapin, isoproterenol, myocardial hypertrophy, superoxide, dismutase