关键词: 膀胱癌, 阿霉素, 聚维酮, 凋亡

Abstract: AIM: To investigate the clinical effects of polyvinylpyrrolidone and adriamycin in preventing postoperative recurrence of superficial bladder cell cancer and its mechanism.METHODS: 231 postoperative cases received intravesical instillation with adriamycin combined with polyvinylpyrrolidone (experiencial group) or isotonic Na chloride combined with adriamycin (control group).Bcl-2 and Bax protein expression was examined by immu-· 750 · Chin J Clin Pharmacol Ther 2006 Jul;11(7)nohistochemistry after 50 cases received intravesical instillation in such way before operation.Concentration and callback rate of adriamycin combined with polyvinylpyrrolidone were examined by ultraviolet analysis.RESULTS: 194 cases were followed.In experimental group, recurrence was found in 24 cases (18.6 %) , hematuria in 2 cases and bladder irritation in 3 cases.In control group,recurrence was found in 39 cases (60.0 %).Compared with control group, Bcl-2 expression in experimenta group has no difference (P>0.05) , Bax expression was up-regulated significantly (P<0.01) and Bcl-2 Bax expression was down-regulated (P<0.05).Polyvinylpyrrolidone and adriamycin could prolong evacuation time 2-4 times as long as NS and adriamycin in bladder.CONCLUSION: Intravesical instillation of polyvinylpyrrolidone and adriamycin are effective for prevention of postoperative recurrence of superficial bladder cell cancerwith fewer side effects Polyvinylpyrrolidone combined with Adriamycin can induce bladder cancer cell apoptosis and prolong medication time in bladder.

Key words: bladder cancer, adriamycin, polyvinylpyrrolidone, apoptosis