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中国临床药理学与治疗学 ›› 2006, Vol. 11 ›› Issue (8): 929-932.

• 研究原著 • 上一篇    下一篇

全氟丙烷白蛋白微球左心超声造影方法及初步临床应用研究

吕清, 王新房, 谢明星, 郑智超, 杨亚利, 卢晓芳, 贺林, 王静, 刘夏天, 袁莉   

  1. 华中科技大学同济医学院附属协和医院超声影像科, 武汉 430022 , 湖北
  • 收稿日期:2006-05-20 修回日期:2006-06-30 出版日期:2006-08-26 发布日期:2020-11-05
  • 作者简介:吕清, 男, 博士, 副教授, 主要从事心血管疾病超声诊断研究。Tel:027-85726430  E-mail:unionlq2003@yahoo.com.cn

Methodology and clinical application of left heart contrast echocardiography with perfluoropropane-albumin microsphere

LV Qing, WANG Xin-fang, XIE Ming-xing, ZHENG Zhi-chao, YANG Ya-li, LU Xiao-fang, HE Lin, WANG Jing, LIU Xia-tian, YUAN Li   

  1. Department of Ultrasound Diagnosis , Union Hospital , Tongji Medical College of Huazhong University of Science and Technology , Wuhan 430022 , Hubei , China
  • Received:2006-05-20 Revised:2006-06-30 Online:2006-08-26 Published:2020-11-05

摘要: 目的 探讨全氟丙烷白蛋白微球注射剂左心超声造影临床应用的可行性。方法 在30 例患者中, 经外周静脉弹丸式注射全氟丙烷白蛋白微球, 进行左心超声造影检查, 观察造影剂注射前后左心室显影等级、心内膜边界增强效果和心肌显影情况。结果 30 例患者中只有1 例患者研究者B 评价左室充盈等级为2 级, 其余29 例患者左室充盈等级均为3 级。研究者A 和B 评价左心室可清晰识别的节段数均显著增加, 研究者A 由3.60 ±0.81 增加至5.93 ±0.25 , 研究者B 由3.50 ±0.73 增加至5.87 ±0.35(P<0.01)。两组研究者分别评价的结果差异无显著性意义(P>0.05), 造影后平均内膜边界增强率为96.6%。30 例患者左室壁心肌组织均获得了满意的显影效果。结论 临床经外周静脉弹丸式注射全氟丙烷白蛋白微球行左心超声造影, 取得了满意的效果。

关键词: 全氟丙烷白蛋白微球, 超声造影心动图, 左心, 临床应用

Abstract: AIM: To evaluate the feasibility of clinical application of left heart contrast echocardiography with perfluoropropane-albuminmicrosphere.METHODS: The left heart contrast echocardiography , using intravenous bolus injection of perfluoropropane-albumin microsphere contrast agent , was performed in the 30 patients.Left heart opacification grades , numbers of border delineation segment and myocardial contrast agent perfusions were observed.Observer A and observers B evaluated the contrast effect respectively by self-comparison between pre-injection and post-injection.RESULTS: Left heart opacification grades of 1 patient is 2 grade by observers B , the others is 3 grade.The numbers of border delineation augment segment increased from 3.60 ±0.81 to 5.93 ±0.25 and from 3.50 ±0.73 to 5.87 ±0.35 by observer A and observers B.Both observers considered the number of clearly recognized endocardial border segments increased significantly.The interobserver difference is not of significance(P>0.05).The average enhancement rate of LV endocardial border was 96.6%.The myocardial contrast agent perfusions of left ventricular walls were clearly visualized in 30 patients.CONCLUSION: Clinical application of intravenous left heart contrast echocardiography with perfluoropropane-albumin microsphere is feasibility and effective.

Key words: perfluoropropane-albumin microsphere, contrast echocardiography, left heart, clinical application

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