全溶性止血纤维的动物试验及临床应用研究

中国临床药理学与治疗学 ›› 2006, Vol. 11 ›› Issue (9): 1017-1020.

全溶性止血纤维的动物试验及临床应用研究

王会敏, 潘吉勇¹, 杨冰², 刘克辛³

大连永兴医用材料有限公司, 大连 116023, 辽宁;
¹大连市第三人民医院骨科, 大连 116000, 辽宁;
²大连市第三人民医院普外科, 大连 116000, 辽宁;
³大连医科大学药学院, 大连 116027, 辽宁

收稿日期:2006-06-01 修回日期:2006-09-07 出版日期:2006-09-26 发布日期:2020-11-05
通讯作者: 刘克辛, 男, 教授, 博士生导师, 研究方向:药物转运蛋白在药代动力学方面的作用。Tel:0411-84721501 　E-mail:kexinliu@dlmedu.edu.cn
作者简介:王会敏, 女, 硕士研究生, 制药工程师, 研究方向:可吸收性止血材料及防粘连材料的研究。Tel:13904096383 E-mail:whm7678@sina.com
基金资助:
本项目为国家级火炬计划项目(No99D231D6520154)

Study of animal trial and clinical use on fully soluble hemostatic fibre

WANG Hui-min, PAN Ji-yong¹, YANG Bing², LIU Ke-xin³

Dalian Yongxing Medical Material Ltd.Co., Dalian 116023 , Liaoning, China;
¹Department of Orthopaedics, the Third People's Hospital, Dalian 116000 , Liaoning, China;
²Department of Chirurgery , the Third People's Hospital Of Dalian City , Dalian 116000 , Liaoning, China;
³College of Pharmacy , Dalian Medical University , Dalian 116027,Liaoning , China

Received:2006-06-01 Revised:2006-09-07 Online:2006-09-26 Published:2020-11-05

摘要/Abstract

摘要： 目的研究全溶性止血纤维(FHF) 的止血效果。方法 30 只家兔, 制作不同的损伤创面以及动静脉损伤模型, 应用不同材料进行止血, 比较止血时间和出血量, 观察不同材料肝素化前后的止血效果;214 例外科手术患者随机分两组, 107 例为实验组应用FHF, 对照组分为明胶海绵组和凡士林油纱组, 比较止血时间和止血效果。结果 FHF 优于明胶海绵的止血效果(p<0.05);动物肝素化前后FHF 止血效果无明显差异, 但与明胶海绵组相比有显著差异(p<0.05);临床实验结果可见, FHF 在止血时间上明显短于对照组。止血效果与对照组比较有明显差别(p<0.05) 。结论全溶性止血纤维止血安全、效果可靠。

关键词: 全溶性止血纤维, 动物实验, 临床实验, 损伤模型, 止血作用

Abstract: AIM: To investigate the hemostatic effect of fully hemostatic fibre (FHF).METHODS: In the animal experiment, 30 rabbits were treated to produce different models of trauma surface and artery and vein trauma.Different materials were used to stopbleeding, in order to compare the hemostasis time and the bleeding volume and observe the difference of hemostatic effect for different materials between before and after the treatment with heparin.A prospective study was designed.Two hundred and fourteen patients admitted in our department due to surgery were divided randomly into test groupand control group.FHF was used in test groupand Glutin Spong and vaseline oil gauze in the control groups for hemostasis with a view to comparing their hemostasis time and effect.RESULTS: It was suggested that the hemostatic effect of FHF had no significant difference with the Surgicel group.FHF and Surgicel groups appeared significant difference with the Glutin Sponge (p<0.05).No significant difference by using FHF was observed between before and after the treatment with heparin, but significant difference (p<0.05) was found in the Glutin Sponge.The results of clinical test suggested that the hemostatic time of FHF was shorter than that of control group.CONCLUSION: The results of animal experiment and clinical test demonstrated that the hemostatic effects of FHF were not only believable, but also safety and convenience.

Key words: fully soluble hemostatic fibre, animal trial, clinic test, trauma model, hemostatic effects

中图分类号:

R965.2

王会敏, 潘吉勇, 杨冰, 刘克辛. 全溶性止血纤维的动物试验及临床应用研究[J]. 中国临床药理学与治疗学, 2006, 11(9): 1017-1020.

WANG Hui-min, PAN Ji-yong<, YANG Bing<, LIU Ke-xin<. Study of animal trial and clinical use on fully soluble hemostatic fibre[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2006, 11(9): 1017-1020.

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