关键词: 多成分代谢网络动力学, 总室模型, 数学模型, 拉氏变换, 药物动力学

Abstract: AIM: To establish a network pharmacoki-netic model for studying multiple drug components and analyzing parameters. METHODS: A model has been set up based on the comparent and linear kinetic theories, and the solutions have been obtained by Laplace transform method. The relations between the whole comp-artment model and network model for multiple component have been comparatively studied and their kinetic parameters have also been estimated and analyzed. RESULTS: The multiple component network pharmacokinetics follow a first order linear mammillary model. C, is a polynomial of power index numbere, which is similar to the whole compartment model. Various parameters (transit constant) were calculated by the expression of matrix consisting of α_i and the compartment parameters. Its kinetic parameters can be obtained on the basis of the whole compartment model. CONCLUSION: The multiple component net-work pharmacokinetic parameters can be obtained and analyzed similarly as the whole compartment model.

Key words: multiple component network pharmacokinetics, whole compartmental model, mathematical model;, Laplace transform, pharmacokinetics