正常和便秘模型动物排便实验研究进展

中国临床药理学与治疗学 ›› 2007, Vol. 12 ›› Issue (12): 1339-1343.

正常和便秘模型动物排便实验研究进展

钱伯初, 史红, 郑晓亮

浙江省医学科学院药物研究所,杭州 310013,浙江

收稿日期:2007-08-20 修回日期:2007-10-09 发布日期:2020-11-10
作者简介:钱伯初,男,研究员,硕士生导师,主要从事中药药理与新药研发。Tel:0571-88215627 E-mail:qianbochu@yahoo.com.en

Survey of studies on defecation in normal and constipated animal model

QIAN Bo-chu, SHI Hong, ZHENG Xiao-liang

Institute of Materia Medica, Zhejiang Academy of Medical Sciences, Hangzhou 310013, Zhejiang, China

Received:2007-08-20 Revised:2007-10-09 Published:2020-11-10

摘要/Abstract

摘要： 近年未用多种方法成功地在大鼠、家兔、狗与猴等动物体内建立了若干新的便秘动物模型与排便实验方法。本文简要介绍这些模型的制作方法及其在药物研究中的应用:药物性便秘动物模型包括阿米替林所致称猴便秘模型,吗啡所致家兔使秘模型,涣莫尼定和吗啡所致雪招弛缓性与症孪性使秘模型,洛啄丁膝所致大鼠便秘模型及对结肠季占液影响的研究;正常动物排便实验包括正常家兔与狗排便实验及清醒猴胃肠收缩活动测量。这些便秘模型制备方法,将有益于抗便秘药物研究时的选择应用。

关键词: 使秘, 排便, 动物模型, 都膜, 需肠道运动

Abstract: In recent years, new methods of defecation experiment in nonnal and constipated animal model have been successfully established in some species such as rats, rabbits, dogs and cynomolgus monkeys induced by several condition. This paper briefly introduced the progress in prepar of defecation in normal and constipated animal models, which was classified into two categories. (1) Drug-induced constipation animal models: Ftriptyline-induced constipation in cynomolgus monkeys, morphine-induced constipated rabbits, brimonidine and morphint induced atonic or spastic constipated ferrets, and loperamide-induced constipated rats and its colonic mucus decreased. (2) Defecation in normal animal models, including defecation in normal rabbits and dogs, measurement of gastrointestinal contractile activity in conscious monkeys. The paper reviewed the progress on methodology of constipated animal model which will be useful for the study on the anticonstipation drugs.

Key words: constipation, defecation, animal model, mucosa, gastrointestinal motility

中图分类号:

R965.2

钱伯初, 史红, 郑晓亮. 正常和便秘模型动物排便实验研究进展[J]. 中国临床药理学与治疗学, 2007, 12(12): 1339-1343.

QIAN Bo-chu, SHI Hong, ZHENG Xiao-liang. Survey of studies on defecation in normal and constipated animal model[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2007, 12(12): 1339-1343.

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