生长抑素抑制大肠癌细胞增殖及机制的研究进展

摘要/Abstract

摘要： 生长抑素是一种广泛存在于中枢神经系统、冒肠道和膜腺组织内的,具有广泛抑制作用的冒肠激素。大量研究表明生长抑素及其类似物具有抗肿瘤活性,能抑制内分泌肿瘤的增殖,且表现出对许多实体肿瘤,尤其是消化系统肿瘤有抑制作用。本文将对近几年关于生长抑素及其类似物影响大肠癌细胞增殖机制的研究进展作一综述。

关键词: 生长抑素, 生长抑素受体, 大肠癌, 信号转导

Abstract: Somatostatin(SS) is an inhibiting gut hormone that widely exists in central nervous system (CNS), gastrointestinal tract, pancreatic tissue. A lot of researches indicate the anticancer activity of somatostatin analogue. It was reported to suppress proliferation of endocrine tumors,especially some solid tumors in digestive system. This review summarizes the progress on mecha-nism of somatostatin analogue(SSTA) and its influences on colon cancer of in recent years.

Key words: somatostatin, somatostatin receptor, coionic neoplasms, signal transduction

中图分类号:

R735.3

刘李, 吴佩. 生长抑素抑制大肠癌细胞增殖及机制的研究进展[J]. 中国临床药理学与治疗学, 2007, 12(12): 1344-1353.

LIU Li, WU Pei. Progress in inhibitory mechanism of somatostatin in the growth of human colonic carcinoma cells[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2007, 12(12): 1344-1353.

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