天然抗氧化剂-抗癌转移的新途径

摘要/Abstract

摘要： 癌转移是引起癌症患者死亡的一个主要原因。癌转移的过程涉及转移相关基因、细胞外基质、癌细胞运动和血管新生。活性氧化物能促进癌转移的发生。抗氧化剂可以通过清除活性氧化物而抑制癌转移的发生。对天然抗氧化剂的抗癌转移活性筛选和结构改造, 是开发高效、无毒副作用抗癌转移药物的一种十分重要的途径。在对多酚类、黄酮类、萜类、维生素类等天然抗氧化物质的开发中, 有望寻得可用于临床病人的抗癌转移药物。

关键词: 天然抗氧化剂, 活性氧化物, 癌, 转移

Abstract: Metastasis is one of the major causes of mortality in cancer patients.The complicated multistep processes of cancer metastasis are involved, refer to gene, extracellular matrix (ECM), motility of cancer cells and angiogenesis.Reactive oxygen species (ROS) is related to each process of metastasis and can promote metastasis of tumour cells.Antioxidant represses the cancer metastasis through scavenging ROS.It is important to develop high performance, non-toxic natural drug from natural antioxidant to inhibit cancer metastasis.The exploration of compounds from polyphenols, flavonoids, terpene, and vitamins may lead to finding new drug for antimetastasis.

Key words: natural antioxidants, reactive oxygen species, cancer, metastasis

中图分类号:

R730.5

杨靖亚, 吴宏忠, 胡怿, 丰俊, 刘建文. 天然抗氧化剂-抗癌转移的新途径[J]. 中国临床药理学与治疗学, 2007, 12(4): 366-370.

YANG Jing-ya, WU Hong-zhong, HU Yi, FENG Jun, LIU Jian-wen. Natural antioxidants-new approaches for suppressing cancer metastasis[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2007, 12(4): 366-370.

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