双黄连溶液对大鼠烫伤、烧伤治疗作用的实验研究

中国临床药理学与治疗学 ›› 2007, Vol. 12 ›› Issue (5): 526-529.

双黄连溶液对大鼠烫伤、烧伤治疗作用的实验研究

李丽华¹, 哈娜¹, 杨孟欢², 孙昭君²

¹哈尔滨医科大学第一临床医学院药学部, ² 药学院,哈尔滨 150001,黑龙江

收稿日期:2006-10-08 修回日期:2007-03-08 发布日期:2020-10-29
作者简介:李丽华,女,本科,副主任药师,研究方向:临床药师。Tel:13804588480 E-mail:lihua520420@yahoo.com.cn

Experimental study of effect of Shuanghuanglian liquor on scalded or burnt rats

LI Li-hua¹, HA Na¹, YANG Meng-huan², SUN Zhao-jun²

¹Fharmaceutial Section of the First Affiliated Hospital ,²Pharmaceutical Section, Harbin Medical University, Harbin 150001, Heilongjiang, China

Received:2006-10-08 Revised:2007-03-08 Published:2020-10-29

摘要/Abstract

摘要： 目的: 研究双黄连溶液对实验大鼠皮肤烫伤、烧伤的治疗作用。方法: 分别制备大鼠背部、足部水烫伤模型及背部酸、碱烧伤模型,分为双黄连溶液治疗组、磺胺嘧啶银组、模型对照组,观察双黄连溶液对大鼠皮肤创面的治疗作用。结果: 双黄连溶液冷湿敷明显缩短烫伤、烧伤后大鼠创面愈合时间,与模型组相比有统计学差异;愈合速度与磺胺嘧啶银组相近,并能使创面积明显缩小。显微镜下观察真皮内皮肤附件结构完整,未见水肿、炎性细化浸润。结论: 双黄连溶液冷湿敷具有促进实验大鼠创面愈合作用。

关键词: 双黄连溶液, 水烫伤, 酸碱烧伤, 创面愈合

Abstract: AIM: To clarify the healing effect of Shuanghuanglian liquor on the wounded surface of the scalded or burnt rats. METHODS: We made rats’scalded or burnt models on backs or feet, respectively. Those rats were divided into three groups :the model group, the sulfadiazine silver treated group and the Shuanghuanglian liquor treated group, in order to observe the healing process of the wounded surface in the three experimental groups. RESULTS : The cold and wet application of Shuanghuanglian liquor could not only shorten the time for the healing of the wounded surface of scalded or burnt rats, but also reduce the size of the wound. The healing rate of Shuanghuanglian liquor was similar to that of sulfadiazine silver group, but was much higher than that of the modeled group. Under the microscope, we observed that the skin appendages in dermis were still in integrity. No edema or inflammatory cell infiltration was found. CONCLUSION: The cold and wet application of Shuanghuanglian liquor shortens the healing course of wounded skin in scald or burnt rats.

Key words: Shuanghuanglian liquor, scald, burn, healing of the wounded surface

中图分类号:

R965.2

李丽华, 哈娜, 杨孟欢, 孙昭君. 双黄连溶液对大鼠烫伤、烧伤治疗作用的实验研究[J]. 中国临床药理学与治疗学, 2007, 12(5): 526-529.

LI Li-hua, HA Na, YANG Meng-huan, SUN Zhao-jun. Experimental study of effect of Shuanghuanglian liquor on scalded or burnt rats[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2007, 12(5): 526-529.