褪黑激素在人视网膜中的作用机制

摘要/Abstract

摘要： 褪黑激素(melatonin, MLT) 是一种具有众多生理功能的吲哚胺类激素, 而视网膜是它在人体内天然的分泌部位之一。MLT 在视网膜中发挥了重要作用, 包括参与调节视网膜功能昼夜节律性变化、抗氧化抗凋亡和调节视网膜神经网络系统等。对于这些作用机制的深入研究, 有助于指导MLT 在眼科的临床应用。本文仅就其在视网膜中的合成、代谢、受体分布及主要功能作一综述。

关键词: 褪黑激素, 视网膜, 昼夜节律性, 抗氧化剂, 神经网络

Abstract: Melatonin(MLT) is an indolakylamine with many physiological functions, and retina is one of its natural secretory portions.Melatonin plays an important role in retina, including regulating diurnal rhythmicity of retina, protecting against oxidation and apoptosis, regulating retinal neural network and so on.Researches on mechanism of action may appreciate ophthalmological clinical application of melatonin.So this article will review on its synthesis, metabolism, acceptors distribution and function in retina.

Key words: melatonin, retina, diurnal rhythmicity, antioxidant, neural network

中图分类号:

R774

黄文礼, 唐敏, 樊莹. 褪黑激素在人视网膜中的作用机制[J]. 中国临床药理学与治疗学, 2007, 12(7): 735-738.

HUANG Wen-li, TANG Min, FAN Ying. Function of melatonin in human retina[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2007, 12(7): 735-738.

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