胆碱能药物在胃食管反流性哮喘治疗中的策略

中国临床药理学与治疗学 ›› 2007, Vol. 12 ›› Issue (9): 965-969.

胆碱能药物在胃食管反流性哮喘治疗中的策略

况晓东, 崔永耀, 王昊, 陈红专

上海交通大学医学院药理教研室, 上海200025

收稿日期:2007-04-26 修回日期:2007-06-28 出版日期:2007-09-26 发布日期:2020-10-30
作者简介:况晓东, 男, 博士, 研究方向:受体药理学;陈红专, 通讯作者, 男, 教授, 博士生导师, 研究方向:受体药理学。Tel:021-63846590-776449 E-mail:yaoli@shsmu.edu.cn
基金资助:
国家自然基金资助项目(30600269);上海科委重点项目(03JC14064)

Therapatic potential of cholinergic drugs in treatment of asthma associated with gastroesophageal reflux

KUANG Xiao-dong, CUI Yong-yao, WANG hao, CHEN Hong-zhuan

Department of Pharmacology, College of Basic Medical Scinences, Shanghai Jiao Tong University, Shanghai 200025, China

Received:2007-04-26 Revised:2007-06-28 Online:2007-09-26 Published:2020-10-30

摘要/Abstract

摘要： 胃食管反流与哮喘的发生有着密切的联系。实验证实迷走神经在食管-支气管哮喘的发生中起一定的作用, 而胆碱能神经递质和胆碱受体可能在胃食管反流性哮喘的发病机制中占有重要的地位,提示抗胆碱能药物在胃食管反流性哮喘的治疗过程中具有潜在的应用前景。

关键词: 胃食管反流, 哮喘, 胆碱受体

Abstract: Gastroesophageal reflux (GER) has a close association with asthma through vagal nerve.Cholinergic nerve and cholinergic receptors might play an important role in the development of GER-induced asthma, indicating that anti-cholinergic drugs may have therapatic potential in the treatment of asthma induced by gastroesophageal reflux.

Key words: gastroesophageal reflux, asthma, cholinergic receptor

中图分类号:

R962

况晓东, 崔永耀, 王昊, 陈红专. 胆碱能药物在胃食管反流性哮喘治疗中的策略[J]. 中国临床药理学与治疗学, 2007, 12(9): 965-969.

KUANG Xiao-dong, CUI Yong-yao, WANG hao, CHEN Hong-zhuan. Therapatic potential of cholinergic drugs in treatment of asthma associated with gastroesophageal reflux[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2007, 12(9): 965-969.

参考文献

1 Vakil N, van Zanten SV, Kahrilas P, et al.The Montreal definition and classification of gastroesophageal reflux disease :a global evidence based consensus [J].Am J Gastroenterol, 2006; 101:1900-1920.
2 Harding SM, Sontag SJ.Asthma and gastroesophageal reflux [J].Am J Gastroenterol, 2000;95:S23-32.
3 Debley JS, Carter ER, Redding GJ.Prevalence and impact of gastroesophageal reflux in adolescents with asthma :a population-based study [J].Pediatr Pulmonol, 2006;41 :475-481.
4 张孔, 梁国庆.支气管哮喘与胃食道反流的临床研究 [J].现代医学与仪器, 2004;1 :5-6.
5 JE Richter.Gastroesophageal reflux disease and asthma :the two are directly related [J].Am J Med, 2000;108:S153-S158.
6 Daoui S, D'agostino B, Gallelli L, et al.Tachykinins and airway microvascular leakage induced by HCl intraoesophageal instillation [J].Eur Respir J, 2002;20:268-273.
7 胡晓慧, 沈飞, 董宁征, 等.抗人基质金属蛋白酶-2 的单抗制备及功能研究 [J].中国病理生理杂志, 2005;21: 876-881.
8 刘春丽, 赖克方, 陈如冲, 等.胃食管反流性咳嗽患者气道黏膜与分泌物中神经肽含量的变化 [J].中华结核和呼吸杂志, 2005;28:520-524.
9 Racké K, Matthiesen S.The airway cholinergic system :physiology and pharmacology [J].Pulm Pharmacol Ther, 2004;17: 181-198.
10 Matsumoto S.Functional evidence of excitatory M₁ receptors in the rabbit airway [J].J Pharmacol Exp Ther, 1997;281:531-539.
11 Walch L, Gascard JP, Dulmet E, et al.Evidence for a M(1) muscarinic receptor on the endothelium of human pulmonary veins [J].Br J Pharmacol, 2000;130 :73-78.
12 Sarria B, Naline E, Zhang Y, et al.Muscarinic M₂ in acetylcholine-isoproterenol functional antagonism in human isolated bronchus [J].Am J Physiol Lung CellMol Physiol, 2002;283: L1125-1132.
13 Bowrey DJ, Peters JH, DeMeester TR.Gastroesophageal reflux disease in asthma :effects of medical and surgical antireflux therapy on asthma control [J].Ann Surg, 2000;231 :161-172.
14 Lammers JW.The role of pirenzepine-sensitive(M₁) muscarinic receptors in vagally mediated bronchoconstriction in humans [J].Am Rev Respir Dis, 1989;139:446-449.
15 Rache K.The airway cholinergic system:physiology and pharmacology [J].Pulm Pharmacol Ther, 2004;17 :181-198.
16 Furchgott RF, Zawadzki JV.The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acety lcholine [J].Nature, 1980;288:373-376.
17 Tracey WR, PeachMJ.Differential muscarinic receptor mRNA expression by freshly isolated and cultured bovine aortic endothelial cells [J].Circ Res, 1992;70 :234-240.
18 Traish AM, Kim N, Carson MP, et al.Characterization of muscarinic acety lcholine receptor in cultured bovine aortic endothelial cells [J].J Recept Res, 1994;14 :153-156.
19 张锦超, 王莉莉, 俞炜源, 等.牛m1 和m5 受体内环3 区的克隆及主动脉内皮细胞上两种受体mRNA 表达的检测 [J].军事医学科学院院刊, 2002;26:241-244.
20 Burns EH JR, Lukomski S, Rurangirwa J, et al.Genetic inactivation of the extracellular cysteine protease enhances in vitro internalization of group A streptococci by human epithelial and endothelial cells [J].Microb Pathog, 1998;24:333-339.
21 Moncada S, Higgs A.The L-arginine-nitric oxide pathway [J]. N Engl JMed, 1993;329:2002-2012.
22 Edwards G, Dora KA, Gardener MJ, et al.K+ is an endothelium-derived hyperpolarizing factor in rat arteries [J].Nature, 1998;396:269-272.
23 Aihara T, Fujishita T, Kanatani K, et al.Impaired gastric secretion and lack of trophic responses to hypergastrinemia in M3 muscarinic receptor knockout mice [J].Gastroenterology, 2003;125:1774-1784.

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