对临床药理学一些基本问题研究的思考

中国临床药理学与治疗学 ›› 2008, Vol. 13 ›› Issue (10): 1081-1085.

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对临床药理学一些基本问题研究的思考

魏伟

安徽医科大学临床药理研究所, 合肥 230032, 安徽

收稿日期:2008-10-08 修回日期:2008-10-20 出版日期:2008-10-26 发布日期:2020-10-19
作者简介:魏伟, 医学博士, 药理学博士生导师, 现任安徽医科大学临床药理研究所所长, 安徽医科大学药学博士后科研流动站站长, 国际药理学联合会临床药理学委员会委员,中国药理学会常务理事, 中国药理学会临床药理学专业委员会主任委员, 中国药理学会抗炎免疫药理学专业委员会副主任委员, 《中国药理学通报》主编, 安徽省政协委员。主编学术著作多部, 包括《抗炎免疫药理学》、《临床药理学新论》、《药理实验方法学》(第四版) , 主译《临床药理学原理》, 主编全国本科生规划教材《临床药理学学习指导及习题集》 ;曾获安徽省科学技术奖一、二、三等奖和安徽青年科技奖等;发表学术论文 200余篇(SCI收录期刊发表 60余篇) ;培养的博士生学位论文 2006 年获得全国优秀博士学位论文提名论文

Consideration of research on some basic problems of clinical pharmacology

WEI Wei

Institute of Clinical Pharmacology, Anhui Medical University, Hefei 230032, Anhui, China

Received:2008-10-08 Revised:2008-10-20 Online:2008-10-26 Published:2020-10-19

摘要/Abstract

摘要： 临床药理学是研究药物与人体相互作用及其规律的一门学科。临床药理学基本原理在药物的临床研究与评价、药物不良反应监测等方面做了大量工作,取得了明显进展。然而,对临床药理学的共性、关键性和前沿性的基本问题研究更应给予高度关注,在进一步做好常规性临床药理学服务工作的同时,积极加强临床药理学学术问题的探索,为临床安全有效合理用药提供理论支撑。药物相互作用、多药耐药(MDR)、遗传药理学、药物基因组学、药动学/药效学(PK/PD)模型、性别药理学、基于药物作用于人体病理组织细胞的药效学和分子机制的研究等临床药理学的共性、关键性和前沿性问题已引起人们的重视。本文就临床药理学研究的一些基本问题的思考作一简述。

关键词: 临床药理学, 基本问题

Abstract: Clinical pharmacology is a subject to study the interactions and rules between drugs and the body .Principles of clinical pharmacology have made significant progress in many aspects, such as clinical trials, and evaluation of new drugs adverse drug reaction monitoring .Much importance should be attached to the study of common, critical and advanced questions in clinical pharmacology .Besides doing the rou-tine service of clinical pharmacology, exploration on academic research should also be strengthened to provide theoretical support to ensure the safety, effectiveness and rationality of clinical drug application .Study on drug interaction, multidrug resistance, pharmacogenetics, pharmacogenomics, PK/PD model, sex phar-macology, pharmacodynamics and molecular mechanism of drug based on pathological histiocyte of human body have attracted people' s attention.Consideration of research on some basic problems of clinical pharmacology were reviewed in this article .

Key words: clinical pharmacology, basic problems

魏伟. 对临床药理学一些基本问题研究的思考[J]. 中国临床药理学与治疗学, 2008, 13(10): 1081-1085.

WEI Wei. Consideration of research on some basic problems of clinical pharmacology[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2008, 13(10): 1081-1085.

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对临床药理学一些基本问题研究的思考

Consideration of research on some basic problems of clinical pharmacology

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