γ-氨基丁酸A型受体在神经精神性疾病发生发展中的意义

中国临床药理学与治疗学 ›› 2008, Vol. 13 ›› Issue (2): 208-212.

γ-氨基丁酸A型受体在神经精神性疾病发生发展中的意义

来艳萍, 刘燕强

南开大学生命科学学院, 天津 300071

收稿日期:2007-07-16 修回日期:2008-01-17 出版日期:2008-02-26 发布日期:2020-10-14
通讯作者: 刘燕强, 男, 教授, 研究方向:神经功能调控。Tel:022-23508378 　E-mail:liuyanq@nankai.edu.cn
作者简介:来艳萍, 女, 硕士研究生, 研究方向:神经功能调控。Tel:13920157402 E-mail:laiyanping275@mail.nankai.deu.cn
基金资助:
国家自然科学基金资助项目(30470223)

Significance of GABA_A receptors in the development of some neuropsychiatric diseases

LAI Yan-ping, LIU Yan-qiang

College of Life Sciences, Nankai University, Tianjin 300071, China

Received:2007-07-16 Revised:2008-01-17 Online:2008-02-26 Published:2020-10-14

摘要/Abstract

摘要： γ-氨基丁酸(GABA) 是中枢神经系统中介导抑制性突触传递的神经递质, 通过GABA_A、GABA_B和GABA_C三种亚型受体介导广泛的生理效应。GABA_A受体亚型是GABA受体中占主导地位的亚型, 可介导GABA的大部分功能, 由来自8个亚基族(α, β, γ, δ, θ, ε, ρ和π)的不同亚基组成,而最典型的GABA_A受体结构是由5个异质性多肽亚基(两个α、两个β和一个γ)组成的五边形寡聚体。不同亚基尤其是不同α亚基组成的亚型介导的生理和药理学效应有所不同。GABA_B受体对焦虑、抑郁、癫痫以及记忆障碍等不同的神经精神性疾病的发生发展有重要的意义, 可能是这些疾病防治药物的作用靶标。

关键词: GABA_A受体, 药理学效应, 神经精神性疾病

Abstract: γ-aminobutyric acid (GABA) is an inhibitory neurotransmitter in the central nervous system (CNS), with wide physiological role via GABA_A, GABA_B and GABA_C receptors. GABA_A receptor, a dominant type of GABA receptors is comprised of different subunits coming from eight subunit clusters. Whereas its typical molecular structure is a hetero-pentameric complex, being comprised of two α, two β and one γ subunits. And different subunits especially different αsubunit combinations give rise to various physiological and pharmacological effects, which makes GABA_A receptor play a great role in the development of some neuropsychiatric diseases such as anxiety, depression, epilepsy and memory disorders etc. Thus GABAA receptor might be an effective target for preventing these neuropsychiatric diseases.

Key words: GABA_A receptor, pharmacological effects, neuropsychiatric disease

中图分类号:

R962

来艳萍, 刘燕强. γ-氨基丁酸A型受体在神经精神性疾病发生发展中的意义[J]. 中国临床药理学与治疗学, 2008, 13(2): 208-212.

LAI Yan-ping, LIU Yan-qiang. Significance of GABA_A receptors in the development of some neuropsychiatric diseases[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2008, 13(2): 208-212.

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