胰腺移植排斥反应及其监测的研究进展

摘要/Abstract

摘要： 器官移植是各种器官衰竭终末期的最佳乃至唯一治疗方法, 而急性排斥反应是导致移植物丧失功能、手术失败的最重要原因。移植胰腺为晚期糖尿病治疗的重要选择, 胰肾联合移植是终末期糖尿病肾病的最佳治疗方法, 如何早期诊断及治疗胰腺移植后急性排斥反应成为移植成败的关键因素。本文就胰腺移植排斥反应监测的研究进展作一综述。

关键词: 胰腺移植, 排斥反应, 细胞因子, Foxp3

Abstract: The syndrome of insulin-dependent diabetes mellitus (IDDM) includes not only abnor-mal glucose metabolism but also specific microvascular complications that include nephropathy, retinopathy and neuropathy. In the short term, improvement in the quality of life and possible prevention of further morbidity associated with diabetes makes pancreas transplantation an important therapeutic option, particularly when combined with a kidney trans-plant, in appropriately selected diabetic patients. The focus of the early management of the pancreas transplant recipient is the prevention of acute rejection. In this article we review the methods for clinical diagnosis of the early acute rejection due to pancreas transplanta-tion.

Key words: pancreas transplantation, rejection, cytokine, Foxp3

中图分类号:

R657.5

曹鋆, 芮景. 胰腺移植排斥反应及其监测的研究进展[J]. 中国临床药理学与治疗学, 2008, 13(2): 234-240.

CAO Jun, RUI Jing. Advance in study of monitoring acute rejection of pancreas allograft transplant[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2008, 13(2): 234-240.

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