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中国临床药理学与治疗学 ›› 2008, Vol. 13 ›› Issue (8): 957-960.

• 综述与讲座 • 上一篇    

胆囊炎病因及其动物模型研究进展

阚红卫, 魏安祥   

  1. 安徽省药物研究所, 安徽省中药研究与开发重点实验室, 合肥230022, 安徽
  • 收稿日期:2008-04-30 修回日期:2008-08-03 出版日期:2008-08-26 发布日期:2020-10-12
  • 作者简介:阚红卫, 男, 硕士, 助理研究员, 研究方向:心血管药理、消化药理。Tel:0551-3632371 E-mail:khw@ada.gov.cn

Progress of etiology and animal model in cholecystitis

KAN Hong-wei, Wei An-xiang   

  1. AnhuiInstitute of Materia Medica, Hefei 230022, Anhui, China
  • Received:2008-04-30 Revised:2008-08-03 Online:2008-08-26 Published:2020-10-12

摘要: 动物模型在胆囊炎的病因研究、发病机理的探索以及治疗措施的评估中都有着不可替代的重要作用。胆囊炎的病因, 与感染、激素、神经、代谢等因素有关。继常规模拟临床的细菌感染造模之后, 总胆管结扎、迷走神经切除、食物喂养、异物植入、药物诱导、狭窄成石等在胆囊炎模型建立中的应用为我们提供了大量能较好模拟人体相应胆囊炎的动物模型, 有助于对药物进行临床前的药效学评价和进一步研究胆囊炎的机制和办法。

关键词: 胆囊炎, 病因, 动物模型

Abstract: The animal models play irreplaceable and vital role in studying the etiology of cholecystitis, exploring its pathogeny and evaluating its treatment measures.The etiopathogenisis of cholecystitis is associated with many factors such as infection, hormone, nerve, metabolism etc.Following simulation clinical bacterium infection models, the application of common duct ligation, vagus nerve excision, food feeding, foreign matter implantation, drug inducing, and stenosis stone formation help to establish a lot of animal models which can simulate the corresponding cholecystitis.All of these models are helpful to evaluate the preclinical pharmacodynamics and further study on the mechanism and treatment measures of cholecystitis.

Key words: cholecystitis, etiology, animal model

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