氯沙坦通过室旁核抑制慢性心衰大鼠肾交感神经兴奋性

中国临床药理学与治疗学 ›› 2009, Vol. 14 ›› Issue (11): 1212-1215.

氯沙坦通过室旁核抑制慢性心衰大鼠肾交感神经兴奋性

桂乐, 朱健华, 陈庆辉

南通大学附属医院心内科, 南通226001, 江苏

收稿日期:2009-10-19 修回日期:2009-11-03 发布日期:2020-10-26
通讯作者: 朱健华, 男, 博士, 教授, 硕导, 研究方向:心脏电生理。E-mail:jhz323@yahoo.com.cn
作者简介:桂乐, 女, 博士, 研究方向:心脏电生理。Tel:13585216371 E-mail:lgui02@hotmail.com

Losartan inhibits renal sympathetic nerve activity in Paraventricular nucleus in chronic heart failure rat

GUI Le, ZHU Jian-hua, CHEN Qing-hui

Department of Cardiology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu, China

Received:2009-10-19 Revised:2009-11-03 Published:2020-10-26

摘要/Abstract

摘要： 目的：研究慢性心衰时室旁核微量注射氯沙坦对心率、血压和肾交感神经的作用, 揭示心衰下丘脑室旁核对肾交感神经活性的调节机制。方法：用SD 大鼠制作心衰模型, 超声心动图检测心功能变化。脑立体定位仪对大鼠室旁核定位, 微量注射氯沙坦(50 nL), 观察心率、血压和肾交感神经活性的变化。结果：超声心动图显示手术组较假手术组左室内径增加(P <0.01), 射血分数降低(P <0.01), 左室内径缩短率降低(P <0.05) 。注射氯沙坦后, 手术组和假手术组的肾交感神经兴奋性降低, 手术组较假手术组降低更为明显。结论：心衰时室旁核内注射氯沙坦可降低肾交感神经兴奋性。

关键词: 慢性心力衰竭, 室旁核, 氯沙坦, 肾交感神经

Abstract: AIM: Left coronary artery ligation (LAD) was used to induce heart failure.Losartan was microinjected into paraventricular nucleus (PVN ), heart rate(HR), blood pressure(BP) and renal sympathetic nerve activity (RSNA) were measured.The mechanism of PVN in chronic heart failure was investigated. METHODS: Sprague-Dawley male rats were selected for LAD ligation for heart failure models, the variation of cardiac function was detected by echocardiography.Losartan was microinjected into PVN, the responses of HR, BP and RSNA were analyzed. RESULTS: Compared with sham group, the level of LV was increased (P <0.01), the levels of EF and FS were decreased in operation group (P <0.01, P < 0.05).The level of RSNA was decreased greater in operation group than that in sham group(P <0.05). CONCLUSION: Losartan microinjection into PVN can decrease the level of RSNA in chronic heart failure.

Key words: heart failure, paraventricular nucleus, losartan, renal sympathetic nerve activity

中图分类号:

R541.6

桂乐, 朱健华, 陈庆辉. 氯沙坦通过室旁核抑制慢性心衰大鼠肾交感神经兴奋性[J]. 中国临床药理学与治疗学, 2009, 14(11): 1212-1215.

GUI Le, ZHU Jian-hua, CHEN Qing-hui. Losartan inhibits renal sympathetic nerve activity in Paraventricular nucleus in chronic heart failure rat[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(11): 1212-1215.

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