乌灵胶囊治疗伴有焦虑状态的胃食管反流病的疗效

中国临床药理学与治疗学 ›› 2009, Vol. 14 ›› Issue (11): 1300-1303.

乌灵胶囊治疗伴有焦虑状态的胃食管反流病的疗效

陈小燕, 闫峻, 蔡振寨, 夏宣平, 郑君杰, 薛战雄

温州医学院附属第二医院消化内科, 温州 325027, 浙江

收稿日期:2009-09-30 修回日期:2009-10-30 发布日期:2020-10-26
通讯作者: 薛战雄,男, 硕士, 主任医师, 主要从事消化内科疑难病症诊治、消化内镜及内镜下治疗。Tel:0577-88816311 E-mail:xuezhanxiong@126.com
作者简介:陈小燕, 女, 硕士, 主治医师, 主要从事胃肠动力学与胰腺病的基础与临床研究。Tel:0577-88816311 　E-mail:cxy dr@sina.com

Effect ofWuling capsule in the treatment of patients with gastroesophageal reflux disease accompanied with anxiety

CHEN Xiao-yan, YAN Jun, CAI Zhen-zhai, XIA Xuan-ping, ZHENG Jun-jie, XUE Zhan-xiong

Department of Gast Roenterology, the 2nd Affiliated Hospital of Wenzhou Medical College, Wenzhou 325027, Zhejiang, China

Received:2009-09-30 Revised:2009-10-30 Published:2020-10-26

摘要/Abstract

摘要： 目的：探讨乌灵胶囊治疗伴焦虑状态的胃食管反流病(GERD) 患者的临床疗效。方法：选择Zung 焦虑自评量表(SAS) 评分≥50 分的64 例GERD 患者, 随机分为2 组, 治疗组32 例给予乌灵胶囊和埃索美拉唑镁肠溶片, 对照组32 例给予埃索美拉唑镁肠溶片;疗程8 周。应用胃食管反流病症状分级及SAS 的评分变化进行疗效评定。结果：治疗8 周末, 治疗组中显效率、总有效率分别为58.9 %和93.1 %, 对照组分别为32.2 %和67.9 %, 有统计学差异。两组内治疗前与治疗后SAS 评分均有统计学差异;治疗后第4 、8 周末治疗组SAS 评分与对照组相比有统计学差异。结论：乌灵胶囊联用埃索美拉唑镁肠溶片能安全有效治疗伴有焦虑状态的GERD 患者。

关键词: 乌灵胶囊, 埃索美拉唑镁肠溶片, 胃食管反流病, 焦虑

Abstract: AIM: To explore the efficacy of Wuling capsule in the treatment of gastroesophageal reflux disease (GERD) accompanied with anxiety. METHODS: 64 patients with gastroesophageal reflux disease accompanied with anxiety(the score of the SAS ≥50) were randomly divided into 2 groups.Study group(n = 32) was treated with Wuling capsule and esomeprazole magnesium tablets for 8 weeks and control group was treated with esomeprazole magnesium tablets.Clinical efficacy was assessed with gastroesophageal reflux symptoms and Zung self-rating anxiety scale (SAS). RESULTS: After 8 weeks treatment, the efficacy rate and total effective rate of study group were 58.6 %and 93.1 %, which were significantly higher than those in the control group(32.2 % and 67.9 %, respectively, P <0.05).Scores of the SAS of both groups were significantly reduced(P <0.01);and scores of the SAS were significantly different between the study group and the control group after 4, 8 weeks treatment(P <0.05, P <0.01). CONCLUSION: Wuling capsule has significant effectiveness and high safety in the treatment of GERD accompanied with anxiety.

Key words: Wuling capsule, esomeprazole magnesium tablets, gastroesophageal reflux disease, anxiety

中图分类号:

R571

陈小燕, 闫峻, 蔡振寨, 夏宣平, 郑君杰, 薛战雄. 乌灵胶囊治疗伴有焦虑状态的胃食管反流病的疗效[J]. 中国临床药理学与治疗学, 2009, 14(11): 1300-1303.

CHEN Xiao-yan, YAN Jun, CAI Zhen-zhai, XIA Xuan-ping, ZHENG Jun-jie, XUE Zhan-xiong. Effect ofWuling capsule in the treatment of patients with gastroesophageal reflux disease accompanied with anxiety[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(11): 1300-1303.

参考文献

[1] Vakil N, van Zanten SV, Kahrilas P, et al.The Montreal definition and classification of gastroesophageal reflux disease:a global evidence -based consensus[J].Am J Gastroenterol, 2006, 101(8):1900-1920.
[2] Lim LG, Ho KY.Gastroesophageal reflux disease at the turn of millennium[J].World J Gastroenterol, 2003, 9(10):2135-2136.
[3] Jansson C, Nordenstedt H, Wallander MA, et al.Severe gastro-oesophageal reflux symptoms in relation to anxiety, depression and coping in a population-based study[J]. Aliment Pharmacol Ther, 2007, 26(5):683-691.
[4] 林三仁, 许国铭, 胡品津, 等.中国胃食管反流病共识意见[J].胃肠病学, 2007, 12(4):233-239.
[5] Wong WM, Lam KF, Lai KC, et al.A validated symptoms questionnaire (Chinese GERDQ) for the diagnosis of gastro- oesophageal reflux disease in the Chinese population[J].Aliment Pharmacol Ther, 2003, 17(11):1407-1413.
[6] 张作记. 行为医学量表手册[J].中国行为医学科学, 2001, 10(特刊):131-132.
[7] Edwards SJ, Lind T, Lundell L.Systematic review:proton pump inhibitors (PPIs) for the healing of reflux oesophagitis- a comparison of esomeprazole with other PPIs[J].Aliment Pharmacol Ther, 2006, 24(5):743-750.
[8] Fass R, Tougas G.Functional heartburn:the stimulus, the pain, and the brain[J].Gut, 2002, 51(6):885-892.
[9] Locke GR 3rd,Weaver AL, Melton LJ 3rd, et al.Psychosocial factors are linked to functional gastrointestinal disorders: a population based nested case -control study[J].Am J Gastroenterol, 2004, 99(2):350-357.
[10] Koloski NA, Talley NJ, Boyce PM.Predictors of health care seeking for irritable bowel syndrome and nonulcer dyspepsia:a critical review of the literature on symptom and psychosocial factors[J].Am J Gastroenterol, 2001, 96(5): 1340-1349.
[11] Barden N, Reul JM, Holsboer F.Do antidep ressants stabilize mood through action on the hypothalami-p ituitary-adrenocortical system[J].Trends Neurosci, 1995, 18(1):6-11.
[12] Cassano GB, Puca F, Scapicchio PL, et al.Paroxetine and fluoxetine effects on mood and cognitive functions in depressed nondemented elderly patients[J].J Clin Psychiartry, 2002, 63(5):396-402.
[13] 马志章, 左萍萍, 陈宛如, 等.乌灵菌粉的镇静作用及其机理研究[J].中国药学杂志, 1999, 34(6):374-377.

[1]	吴雄志, 王宣, 徐四七, 居霞, 王胜斌, 陈永权. 咪达唑仑口服溶液比右美托咪定喷鼻更有效缓解儿童术前焦虑[J]. 中国临床药理学与治疗学, 2023, 28(6): 666-670.
[2]	丁露露，郭建友. 特质焦虑的神经生物学因素及其对个体认知表现的影响[J]. 中国临床药理学与治疗学, 2020, 25(1): 101-106.
[3]	林敏，沈仲夏，钱敏才，崔力军，任列，蔡敏，沈鑫华. 5-羟色胺转运体基因多态性与抗抑郁剂治疗广泛性焦虑障碍疗效的关联[J]. 中国临床药理学与治疗学, 2019, 24(8): 903-909.
[4]	周严灿. 阿戈美拉汀治疗抑郁障碍的疗效及对脑源性神经营养因子的影响[J]. 中国临床药理学与治疗学, 2019, 24(6): 699-703.
[5]	蔡丹丹, 桂冬辉, 张建兵, 周文华. 小剂量利培酮联合曲唑酮应用于海洛因成瘾脱毒期的疗效分析[J]. 中国临床药理学与治疗学, 2019, 24(1): 94-98.
[6]	常永丽，王春雷，原丽，郭晓姝，韩玲娜. 外侧隔GABA_A受体在帕金森病模型大鼠焦虑样行为中的作用[J]. 中国临床药理学与治疗学, 2018, 23(7): 734-742.
[7]	周严灿，平晶，单建敏. 乌灵胶囊联合阿戈美拉汀对女性抑郁伴睡眠障碍患者的疗效及对神经递质和内分泌激素的影响[J]. 中国临床药理学与治疗学, 2018, 23(12): 1415-1419.
[8]	龚晓兵，李淑珍，黄叶盛，马彦，柳永刚，蒋亚斌，杨见权. 坦度螺酮治疗伴有焦虑抑郁的功能性消化不良的疗效及对生存质量的影响[J]. 中国临床药理学与治疗学, 2017, 22(6): 664-667.
[9]	徐道祥，史惠敏，林小东. 盐酸帕罗西汀联合丹栀逍遥丸治疗抑郁症伴焦虑的临床对照研究[J]. 中国临床药理学与治疗学, 2017, 22(3): 321-325.
[10]	杨琴，杜青，赵洪庆，王宇红，韩远山，杨蕙，孟盼 . 百合疏肝安神汤对焦虑性抑郁症模型大鼠前额叶-边缘结构及GR/BDNF/NPY表达的影响[J]. 中国临床药理学与治疗学, 2017, 22(10): 1090-1098.
[11]	刘晓萍，赖香茂，王海全，陈玉梅，张冬梅. 药物整合在慢性阻塞性肺疾病合并焦虑抑郁障碍患者中的应用价值[J]. 中国临床药理学与治疗学, 2016, 21(9): 1038-1041.
[12]	刘悦, 沈雯雯, 黄燕燕, 张建兵, 周文华. 曲唑酮联合心理治疗对海洛因依赖者脱毒期的疗效观察[J]. 中国临床药理学与治疗学, 2015, 20(5): 578-582.
[13]	王晓倩，郭风莲，沈伶俐，林勇. 度洛西汀联合认知治疗对慢性盆腔疼痛伴发焦虑、抑郁的对照研究[J]. 中国临床药理学与治疗学, 2015, 20(12): 1418-1422.
[14]	叶夷露，徐佳妮，吴丽君，刘丹丹，张琦，吕圭源. 黄连解毒汤对mCPP诱导焦虑样行为的作用研究[J]. 中国临床药理学与治疗学, 2015, 20(11): 1227-1232.
[15]	沈仲夏,沈鑫华,蔡敏,方瑜,林敏,杨剑虹,许毅. 艾司西酞普兰快速剂量滴定治疗广泛性焦虑障碍的对照研究[J]. 中国临床药理学与治疗学, 2014, 19(11): 1263-1267.