祛瘀宁心丸治疗不稳定型心绞痛的疗效及其血清C-反应蛋白的影响

中国临床药理学与治疗学 ›› 2009, Vol. 14 ›› Issue (5): 582-585.

祛瘀宁心丸治疗不稳定型心绞痛的疗效及其血清C-反应蛋白的影响

史海霞¹, 黄继汉², 李庆海³, 卞卡^1,4,5

¹上海中医药大学穆拉德中药现代化研究中心, ²上海中医药大学药物临床研究中心,上海201203;
³ 河南中医学院第三附属医院, 郑州450008, 河南;
⁴美国德克萨斯大学休斯顿医学院综合生物及药理学系, 德克萨斯大学分子医学研究所, 休斯顿TX77030;
⁵上海高校一氧化氮与炎症医学E 研究院, 上海201203

收稿日期:2008-12-27 修回日期:2009-03-23 发布日期:2020-11-09
通讯作者: 李庆海, 男, 主任医师, 教授, 硕士生导师, 研究方向:中西医结合防治心血管疾病研究。Tel:0371-65575586 E-mail:Lqh960918 @sina.com;卞卡, 男, 医学博士, 教授, 博士生导师, 研究方向:一氧化氮与炎症医学。Tel:021-51322535 E-mail:Ka. Bian @uth. tmc.edu
作者简介:史海霞, 女, 在读博士生, 研究方向:心血管药理和炎症医学研究工作。Tel:13816430563

Effects of Quyuningxin pill to unstable angina pectoris efficacy and serum C-reactive protein

SHI Hai-xia¹, HUANG Ji-han², LI Qing-hai^1,3, BIAN Ka^{1,4, 5}

¹Murad Research Center for Modernized Chinese Medicine, ²Shanghai University of Traditional Chinese Medicine,Shanghai 201203, China;
³Third Affiliated Hospital of Henan College of Traditional Chinese Medicine, Zhengzhou 450008, China;
⁴Department of Integrative Biology and Pharmacology, Institute of Molecular Medicine, Texas Medical University, TX77030, USA.;
⁵E-Institute of Shanghai Universities, Division of NitricOxide and Inflammatory Medicine, Shanghai 201203, China

Received:2008-12-27 Revised:2009-03-23 Published:2020-11-09

摘要/Abstract

摘要： 目的:观察祛瘀宁心丸对冠心病不稳定型心绞痛(UA) 患者的临床疗效及其血清C-反应蛋白(CRP) 浓度的影响, 探讨其治疗不稳定型心绞痛的作用机制。方法:将符合入选标准的60 例UA 患者随机分为西药常规治疗加祛瘀宁心丸组(治疗组, 30 例) 和西药常规治疗组(对照组, 30例), 疗程均为4 周, 观察患者心绞痛、临床证候及心电图改变情况。并分别于治疗前后检测患者血清CRP 浓度。结果:治疗组心绞痛缓解率、临床证候及心电图总有效率分别高于对照组(89. 29% 、89. 29% 、75. 0% vs 66. 67% 、66. 67% 、55. 56%, P <0. 05); 治疗组治疗后CRP 浓度低于对照组(3. 8 ±0. 9 vs 5. 8 ±1. 8, P <0. 05) 。结论:祛瘀宁心丸能够显著改善不稳定型心绞痛(浊瘀互结证) 患者的心肌缺血、缺氧, 缓解心绞痛及心电图表现。

关键词: 祛瘀宁心丸, 冠心病不稳定型心绞痛, 浊瘀互结证, C-反应蛋白

Abstract: AIM:To observe the clinical effect of Quyuningxin pill on the serum concentration of C-reactive protein (CRP) from coronary heart disease (CHD) patients with unstable angina pectoris, and explore the related mechanisms. METHODS:Sixty patients of CHD with unstable angina pectoris were divided randomly into treatment group (30 cases) and control group (30 cases). The treatment group was given conventional western medical combined with Quyuningxin pill. The control group was given conventional western medical only. The course of treatment lasted for four weeks.The serum CRP concentration was measured before and after treatment. The changes of angina pectoris and other clinical syndrome as well as electrocardiogram were also observed. RESULTS:The serum concentration of CRP of Quyuningxin pill treated group was decreased markedly comparing with that of control group (3. 8 ±0. 9 vs 5. 8 ±1. 8, P <0. 05). After the treatment, the total effective rate of angina pectoris remission, clinical syndrome, electrocardiogram in treatment group were significantly higher than those in the control group (89. 29%, 89. 29%, 75. 0% vs 66. 67%, 66. 67%, 55. 56% P <0. 05). CONCLUSION: Quyuningxin pill can significantly improve myocardial ischemia related symptoms together with the serum CRP concentration in the patients with unstable angina pectoris.

Key words: Quyuningxin pill, unstable angina pectoris, Zhuoyuhujie syndromes, C-reative protein

中图分类号:

R541

史海霞, 黄继汉, 李庆海, 卞卡. 祛瘀宁心丸治疗不稳定型心绞痛的疗效及其血清C-反应蛋白的影响[J]. 中国临床药理学与治疗学, 2009, 14(5): 582-585.

SHI Hai-xia, HUANG Ji-han, LI Qing-hai, BIAN Ka. Effects of Quyuningxin pill to unstable angina pectoris efficacy and serum C-reactive protein[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(5): 582-585.

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