脉络宁注射液治疗脑梗死的系统评价

中国临床药理学与治疗学 ›› 2009, Vol. 14 ›› Issue (6): 650-654.

脉络宁注射液治疗脑梗死的系统评价

石庆平, 丁峰, 朱锦秀, 程鹏, 许善初, 刘雁

蚌埠医学院第一附属医院药剂科, 蚌埠 233004, 安徽

收稿日期:2009-02-02 修回日期:2009-06-12 出版日期:2009-06-26 发布日期:2020-10-27
作者简介:石庆平,男,硕士,副主任药师,研究方向:临床药学。Tel:0552-3065453 E-mail:sir-shi@126.com

A Meta analysis on the effectiveness and safety of Mailuoning injection on cerebral infarction system

SHI Qing-ping, DING Feng, ZHU Jin-xiu, CHENG Peng, XU Shan-chu, LIU Yan

Department of Pharmacy, the First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, Anhui, China

Received:2009-02-02 Revised:2009-06-12 Online:2009-06-26 Published:2020-10-27

摘要/Abstract

摘要： 目的: 系统评价脉络宁注射液治疗脑梗死的有效性和安全性。方法: 应用国际Cochrane 协作网系统方法评价脉络宁注射液治疗脑梗死的临床随机对照试验(RCT)。计算机检索Cochrane 临床对照试验资料库, 纳入脉络宁注射液治疗脑梗死的RCT 。由两名评价者独立提取资料并进行质量评估。试验数据的统计分析采用Cochrane 协作网提供的Rev Man 5.0.17.0 软件。结果: 最终纳入了13 个RCT 并对其疗效进行了Meta 分析, 表明脉络宁注射液治疗脑梗死与对照组相比, 疗效差异有统计学意义[OR 4.01, 95%CI (2.75,5.84),P<0.00001];均未报道脉络宁注射液引起的严重系统性不良反应。结论: 现有临床证据表明, 脉络宁注射液治疗脑梗死的有效性和安全性相比, 疗效可能优于对照组, 但不是肯定的结论。

关键词: 脉络宁注射液, Meta 分析, 脑梗死, 随机对照试验

Abstract: AIM: To evaluate the effectiveness and safety of Mailuoning injection on cerebral infarction system. METHODS: A systematic review of randomized controlled trials (RCT)of Mailuoning injection on cerebral infarction system was performed.Trials were identified by searching the Cochrane Library (issue 12, 2008),MEDL I NE (1966-2008), BMBASE (1984-2008) and CNKI (1979-2008).Two authors assessed the quality and reviewed the data independently.Statistical analysis was performed by using Rev Man 5.0.17.0. RESULTS: Thirteen trials ranked high quality were included.Meta-analysis of the treatment of Mailuoning injection on cerebral infarction system showed there were no significant differences between Mailuoning injection and the control group [OR 0.72, 95%CI 0.47 to 1.11), P=0.23].No serious systematical adverse reaction was recorded in the two trails. CONCLUSION: Mailuoning injection is an more effective and safe regimen for the treatment of cerebral infarction system than control group probably, but not certain.

Key words: Mailuoning injection, Meta analysis, cerebral infarction, randomized controlled trials

中图分类号:

R911
R969

石庆平, 丁峰, 朱锦秀, 程鹏, 许善初, 刘雁. 脉络宁注射液治疗脑梗死的系统评价[J]. 中国临床药理学与治疗学, 2009, 14(6): 650-654.

SHI Qing-ping, DING Feng, ZHU Jin-xiu, CHENG Peng, XU Shan-chu, LIU Yan. A Meta analysis on the effectiveness and safety of Mailuoning injection on cerebral infarction system[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(6): 650-654.

参考文献

[1] 朱廷彦.奥扎格雷钠注射液治疗脑梗死60 例疗效观察[J].实用全科医学杂志, 2004, 2(6):542-543.
[2] 白敏, 靳海英, 马萍.脉络宁治疗脑梗死62 例临床观察[J].海南实用神经学杂志, 2001, 14(15):54.
[3] 贝光明, 曾红儒.脉络宁注射液对急性脑梗死患者血液流变学的作用及疗效观察[J].中国中西医结合急救杂志, 2006, 13(6):373-374.
[4] 丁邦厚, 周桂苹.脉络宁治疗急性脑梗死53 例临床观察[J].实用医技杂志, 2005, 12(6):1631.
[5] 耿宝剑.脉络宁注射液治疗脑梗死50 例临床疗效观察[J].深圳中西医结合杂志, 2003, 13(2):98-99.
[6] 黄小平, 齐梅.脉络宁治疗脑梗死疗效观察[J].中国民政医学杂志, 2000, 7(9):7.
[7] 梁彩霞, 李庆凤.脉络宁治疗急性脑梗死25 例临床观察[J].现代中西医结合杂志, 2001, 10(14):1337.
[8] 刘彬, 姜萍, 吴丽萍.脉络宁治疗脑梗死临床观察[J].实用医技杂志, 2005, 25(6):16.
[9] 卢影, 王金荣.脉络宁治疗脑梗塞156 例临床观察[J].临床研讨, 1998, 7(6):44.
[10] 潘晓蓉, 陈开珍.脉络宁治疗脑梗死48 例临床观察[J].贵州医药, 2000, 24(3):191.
[11] 司娟娟.脉络宁治疗脑梗塞临床疗效观察[J].中原医刊, 2000, 27(5):49-50.
[12] 孙彩虹.脉络宁注射液治疗急性脑梗塞50 例临床疗效观察[J].哈尔滨医药, 2002, 22(1):24.
[13] 杨秀红.脉络宁治疗急性脑梗塞97 例疗效观察[J].张家口医学院学报, 2003, 20(3):22.
[14] 朱继学, 刘蕴.脉络宁治疗脑梗塞疗效观察[J].山东医药工业, 1998, 17(2):51-52.
[15] 陈爱群, 贾晋生, 李莉.70 例脉络宁注射液不良反应文献分析[J].药物不良反应杂志, 2003, 1(2):162-164.
[16] 富振英.Meta Analysis 研究资料的统计分析方法[J].药物流行病学杂志, 1994, 3:220-222.
[17] DeCoster, Meta-analysis Notes.Retrieved [OJ EB] http://www.stat-help.com/notes.html, 19. J. 2004:1-50.