关键词: 活性维生素D₃, 维持性血液透析, 炎症, 继发性甲状旁腺功能亢进

Abstract: AIM: To explore the effect of activated Vitamin D₃ treatment onmicroinflammation state in maintenance hemodialysis patients. METHODS: 33 maintenance hemodialysis patients with intact parathyroid hormone(iPTH) levels above 300 pg/mL were received activated Vitamin D₃ orally pulse therapy for 12 weeks. Serum iPTH, calcium, phosphorus and inflammatory markers interleukin-6 (IL-6) and C-reactive protein (CRP) were tested before and 4, 12 weeks after the treatment.Echocardiographic parameters of left ventricular hypertrophy were examined before and after the the treatment. RESULT: Both 4 weeks and 12 weeks after 1, 25(OH)₂D₃ treatment, serum IL-6 and CRP levels were reduced significantly.4 weeks after the treatment, serum iPTH levels had no significant change.12 weeks after the treatment, serum iPTH levels were decreased remarkably compared to that before 1, 25 (OH)₂D₃ treatment.Compared with before treatment, the iPTH level was decreased after 12 weeks treatment, 48.5% of the patients reached end-point parameter (iPTH<300 pg/mL).Left ventricular hypertrophy parameters determined by echocardiography were significantly improved after 12 weeks treatment. CONCLUSION: Activated vitamin D₃ can attenuate the microinflammation state in maintenance hemodialysis patients and improve left ventricular hypertrophy.These data suggest that activated vitamin D₃ may have broad application other than modulating calcium, phosphorus metabolism and controlling iPTH in maintenance hemodialysis patients.

Key words: activated Vitamin D₃, maintenance hemodialysis, inflammation, secondary hyperparathyroidism