生长抑素治疗肝纤维化研究进展

中国临床药理学与治疗学 ›› 2009, Vol. 14 ›› Issue (6): 707-710.

生长抑素治疗肝纤维化研究进展

许小兵, 杨妙芳, 朱人敏

南京医科大学南京临床医学院(南京军区南京总医院) 消化内科, 南京 210002, 江苏

收稿日期:2009-04-01 修回日期:2009-05-24 出版日期:2009-06-26 发布日期:2020-10-27
通讯作者: 朱人敏, 男, 医学博士, 主任医师, 博士生导师, 研究方向:消化系统疾病。Tel:13951781534 E-mail:cat409@126.com
作者简介:许小兵,男,医学硕士研究生,住院医师,研究方向:消化系统疾病。

Advancement on the therapy of somatostatin on liver fibrosis

XU Xiao-bing, YANG Miao-fang, ZHU Ren-min

Department of Gastroenterology, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, Jiangsu, China

Received:2009-04-01 Revised:2009-05-24 Online:2009-06-26 Published:2020-10-27

摘要/Abstract

摘要： 生长抑素是人体内广泛分布的环肽激素,近期有研究表明生长抑素能够减少星状细胞分泌细胞因子及细胞外基质, 抑制其增殖及收缩, 并促进其凋亡;同时调节枯否细胞分泌功能, 介导肝干细胞归巢, 对于各种病因肝纤维化尤其对于血吸虫性肝纤维化具有治疗作用。

关键词: 生长抑素, 肝星状细胞, 肝纤维化, 肝硬化, 血吸虫

Abstract: Somatostatin, a cyclopeptide hormone, is generally distributed in vivo.Some studies have indicated that somatostatin can reduce proinflammatory cytokine in hepatic stellate cells and extracellular matrix, and inhibit their proliferation and contraction, promote their apoptosis.It can also regulate the function of Kupffer cells, influence the homing of hepatic stem cells.Somatostain has therapeutic effect on liver fibrosis, especially on the liver fibrosis caused by schistosoma mansoni.

Key words: somatostatin, hepatic stellate cell, hepatic fibrosis, liver cirrhosis, schistosoma mansoni

中图分类号:

R575

许小兵, 杨妙芳, 朱人敏. 生长抑素治疗肝纤维化研究进展[J]. 中国临床药理学与治疗学, 2009, 14(6): 707-710.

XU Xiao-bing, YANG Miao-fang, ZHU Ren-min. Advancement on the therapy of somatostatin on liver fibrosis[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(6): 707-710.

参考文献

[1] Weckbecker G, Lewis I, Albert R, et al.Opportunities in somatostatin research:biological, chemical and therapeutic aspects[J].Nat Rev Drug Discov, 2003, 2(12):999-1017.
[2] Olias G, Viollet C, Kusserow H, et al.Regulation and function of somatostatin receptors[J].Neurochem, 2004, 89(1):1057-1091.
[3] Reynaert H, Rombouts K, Vandermonde A, et al.Expression of somatostatin receptors in normal and cirrhotic human liver and in hepatocellular carcinoma[J].Gut, 2004, 53(8):1180-1189.
[4] 宋盛晗, 冷希圣, 李涛, 等.大鼠肝星状细胞中生长抑素受体表达的研究[J].中华肝脏病杂志, 2005, 13(2):152-153.
[5] 潘勤, 李定国, 陆良勇, 等.生长抑素受体与肝星状细胞活化的相关性研究[J].胃肠病学和肝病学杂志,2004, 13(5):507-510.
[6] McCuskey RS.Anatomy of efferent hepatic nerves[J]. Anat Rec A Discov Mol Cell Evol Biol, 2004, 280(1):821-826.
[7] Pan Q, Li DG, Lu HM, et al.Antiproliferative and proapoptotic effects of somatostatin on activated hepatic stellate cells[J].World J Gastroenterol, 2004, 10(7):1015-1018.
[8] 尹凤荣, 张晓岚.奥曲肽抑制骨桥蛋白刺激的肝星状细胞增殖[J].中国病理生理杂志, 2006, 22(9):1848-1849.
[9] 吴文娟, 朱人敏, 许小兵, 等.奥曲肽对四氯化碳诱导大鼠肝纤维化作用的研究[J].肝脏, 2008, 13(6):394-396.
[10] Lang A, Sakhnini E, Fidder HH, et al.Somatostatin inhibits pro-inflammatory cytokine secretion from rat hepatic stellate cells[J].Liver Int, 2005, 25(4):808-816.
[11] 宋盛晗, 冷希圣, 李涛, 等.生长抑素类似物奥曲肽对肝星状细胞结缔组织生长因子基因表达的影响[J].中华外科杂志, 2004, 42(09):551-553.
[12] Reynaert H, Rombouts K, Jia Y, et al.Somatostatin at nanomolar concentration reduces collagen I and III synthesis by, but not proliferation of activated rat hepatic stellate cells[J].Br J Pharmacol, 2005, 146(4):77-88.
[13] Ding HG, Wang BE, Jia JD, et al.Effects of octreotide on expression of L-type voltage-operated calcium channels and on intracellular Ca²⁺ in activated hepatic stellate cells [J].Chin Med J, 2004, 117(6):913-916.
[14] Reynaert H, Vaeyens F, Qin H, et al.Somatostatin suppresses endothelin-1-induced rat hepatic stellate cell contraction via somatostatin receptor subtype 1[J].Gastroenterology, 2001, 121(4):915-930.
[15] Chao TC, Chao HH, Lin JD, et al.Somatostatin and octreotide modulate the function of Kupffer cells in liver cirrhosis[J].Regulatory Peptides, 1999, 79(2):117-124.
[16] Xidakis C, Ljumovic D, Manousou P, et al.Production of pro-and anti-fibrotic agents by rat Kupffer cells;the effect of octreotide[J].Dig Dis Sci, 2005, 50(5):935-941.
[17] Lowes KN, Croager EJ, Olynyk JK, et al.Oval cell mediated liver regeneration:role of cytokines and growth factors[J].J Gastroenterol Hepatol, 2003, 18(1):4-12.
[18] Jung Y, Oh SH, Zheng D, et al.A potential role of somatostatin and its receptor SSTR4 in the migration of hepatic oval cells[J].Lab Invest, 2006, 86(5):477-489.
[19] Chatterjee S, Mbaye A, Alfidja AT, et al.Circulating Levels of the neuropeptide hormone somatostatin may determine hepatic fibrosis in Schistosoma mansoni infections [J].Acta Tropica, 2004, 90(2):191-203.
[20] Chatterjee S, Vrolix G, Depoortere I, et al.The therapeutic effect of the neuropeptide hormone somatostatin on Schistosoma mansoni caused liver fibrosis[J].BMC Infect Dis, 2005, 5(1):5-45.
[21] Chatterjee S, Op De Beeck J, Rao AV, et al.Prolonged somatostatin therapy may cause down-regulation of SSTRlike GPCRs on Schistosoma mansoni[J].Vector Borne Dis, 2007, 44(3):164-180.