毛发中药物浓度的定量及其在药物监测中的应用

中国临床药理学与治疗学 ›› 2009, Vol. 14 ›› Issue (6): 715-720.

• 综述与讲座 • 上一篇

毛发中药物浓度的定量及其在药物监测中的应用

张玉山, 宋建国

皖南医学院药理教研室, 芜湖 241001, 安徽

收稿日期:2009-03-07 修回日期:2009-05-28 出版日期:2009-06-26 发布日期:2020-10-27
通讯作者: 宋建国, 男, 博士, 教授, 研究方向:时间药理学与数学药理学。Tel:13905535771 E-mail:zys769025600@126.com
作者简介:张玉山,男,硕士研究生,研究方向:数学药理学。Tel:13866364385 E-mail:zys501@163.com

Quantitation of drug concentration in hair and its application in drug monitoring

ZHANG Yu-shan, SONG Jian-guo

Department of Pharmacology, Wannan Medical College, Wuhu 241001, Anhui, China

Received:2009-03-07 Revised:2009-05-28 Online:2009-06-26 Published:2020-10-27

摘要/Abstract

摘要： 毛发取样方便、无创伤性, 并能提供长期可靠的用药信息, 有着血液、尿液等生物样品不可替代的优势。本文对药物毛发分析的研究现状进行了综述。介绍了毛发的结构, 药物进入毛发的机制, 毛发中药物的提取纯化方法及现有分析检测技术;讨论了毛发分析的优缺点, 并对毛发在药物监测中的应用进行了展望。

关键词: 毛发, 分析, 定量, 监测

Abstract: Hair can be easily collected, the collection method does not cause any harm to body.It can provide long and convinced information about drug uses.It possess irreplaceable advantages of blood, urine and other biological samples.The review summarizes the basic information and recent studies of hair analysis.It introducs the hair-shaft structure, the mechanisms of drug incorporation, extraction/purification methods and all kinds of analytical techniques.The advantages, drawbacks and promising prospects about hair in drug monitoring are also discussed.

Key words: hair, analysis, quantitation, monitoring

中图分类号:

R917

张玉山, 宋建国. 毛发中药物浓度的定量及其在药物监测中的应用[J]. 中国临床药理学与治疗学, 2009, 14(6): 715-720.

ZHANG Yu-shan, SONG Jian-guo. Quantitation of drug concentration in hair and its application in drug monitoring[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(6): 715-720.

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毛发中药物浓度的定量及其在药物监测中的应用

Quantitation of drug concentration in hair and its application in drug monitoring

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