舒胆通颗粒防治胆石症的实验研究

中国临床药理学与治疗学 ›› 2009, Vol. 14 ›› Issue (9): 1028-1031.

舒胆通颗粒防治胆石症的实验研究

陆红¹, 张信岳², 刘芳芳¹, 刘萍¹, 金少圣¹

¹浙江中医药大学药学院, 杭州310053, 浙江;
²浙江医药学科学院药物研究所, 杭州310013, 浙江

收稿日期:2009-05-12 修回日期:2009-09-20 发布日期:2020-11-03
作者简介:陆红, 女, 硕士, 副教授, 主要从事中药药理研究。Tel:0571-86613603 E-mail: luhong03@hotmail.com
基金资助:
浙江省中管局资助项目(2006C021)

Experimental study on Shu Dan Tong granules in prevention and frecatment effects of cholelithiasis

LU Hong¹, ZHANG Xin-yue², LIU Fang-fang¹, LIU Ping¹, JIN Shao-sheng¹

¹School of Pharmacy, Zhejiang University of Chinese Medicine, Hangzhou 310053, Zhejiang, China;
²Institute of Materia Medica, Zhejiang Academy of Medical Sciences, Hangzhou 310013, Zhejiang, China

Received:2009-05-12 Revised:2009-09-20 Published:2020-11-03

摘要/Abstract

摘要： 目的: 观察舒胆通颗粒对豚鼠实验性胆石症的防治作用。方法: 62 只DHA 系豚鼠随机分为正常组、模型对照组、阳性对照组(复方胆通胶囊, 0.6 g/kg) 以及舒胆通颗粒5 、10 、20 g (按生药量折算, 下同) kg 剂量组, 除正常组外均采用高胆固醇低蛋白致石饲料喂养复制胆石症模型, 同时灌胃给药连续70 d, 观察豚鼠一般状况、结石形成、胆汁分泌及其成分、血液生化等方面的变化。结果: 舒胆通颗粒5 、10 、20 g/kg 剂量能明显改善胆石症豚鼠一般状况, 降低结石形成比率, 提高胆汁中总胆汁酸(TBA) 含量, 10 、20 g/kg 并能明显提高胆汁分泌量以及血浆胆囊收缩素(CCK) 含量,降低血清TC 水平。结论: 舒胆通颗粒对胆石症豚鼠模型有较好的防治作用。

关键词: 舒胆通颗粒, 胆石症, 防治作用, 实验研究

Abstract: AIM: To observe the prevention and cure effects of Shu Dan Tong granules(SDT) on experimental cholelithiasis in guinea pigs. METHODS: 62 DHA guinea pigs were randomly divided into normal group, model control group, positive control group, as well as SDT 5, 10, 20 g (crude drug, the same below)/ kg dose group, feed with high cholesterol and low protein lithogenic diet in addition to the normal group, and all guinea pigs in different group were given corresponding drugs simultaneously by gavage administration for 70 days, and the general condition, stone formation, bile secretion and composition, blood biochemistry were observerd or detected. RESULTS: SDT can significantly improve the general condition of cholelithiasis in guinea pigs, lower lithogenesis rate and improve total bile acid (TBA) content in doses of 5, 10, 20 g/kg, and can significantly improve the bile secretion and plasma cholecystokinin (CCK) levels, lower serum total cholesterol (TC) levels in doses of 10, 20 g/kg. CONCLUSION: SDT has the prevention and cure effects on cholelithiasis modle of guinea pigs.

Key words: Shu Dan Tong granules, cholelithiasis, prevention and cure effects, experimental study

中图分类号:

R965.2

陆红, 张信岳, 刘芳芳, 刘萍, 金少圣. 舒胆通颗粒防治胆石症的实验研究[J]. 中国临床药理学与治疗学, 2009, 14(9): 1028-1031.

LU Hong, ZHANG Xin-yue, LIU Fang-fang, LIU Ping, JIN Shao-sheng. Experimental study on Shu Dan Tong granules in prevention and frecatment effects of cholelithiasis[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(9): 1028-1031.

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