β-榄香烯对早期实验性变态反应性脑脊髓炎小鼠视神经炎的治疗作用

中国临床药理学与治疗学 ›› 2010, Vol. 15 ›› Issue (10): 1128-1132.

β-榄香烯对早期实验性变态反应性脑脊髓炎小鼠视神经炎的治疗作用

张荣伟¹, 陈蕾²

¹中国医科大学附属第一医院老年病干诊科, ²眼科,沈阳 110001,辽宁

收稿日期:2010-08-05 修回日期:2010-10-21 发布日期:2020-09-16
作者简介:张荣伟,女,副教授,研究方向:神经免疫学。Tel: 13889368255 E-mail: zhangrongwei916@sina.com
基金资助:
辽宁省教育厅资助项目(2009A733)

Therapeutic effect of β-elemene on early optic neuritis in experimental allergic encephalomyelitis mice

ZHANG Rong-wei¹, CHEN Lei²

¹Department of Geriatrics, ²Department of Ophthalmology, First Affiliated Hospital, China Medical University, Shenyang 110001, Liaoning, China

Received:2010-08-05 Revised:2010-10-21 Published:2020-09-16

摘要/Abstract

摘要： 目的: 探讨β-榄香烯对实验性变态反应性脑脊髓炎(experimental allergic encephalomyelitis,EAE)小鼠早期视神经炎的神经保护作用。方法: 通过形态学观察EAE模型组及β-榄香烯干预组小鼠视神经的病理学改变;免疫组化方法检测二组视神经β淀粉样前体蛋白(β-amyloid precursor proteinβ,β-APP)、2,3-环核苷3磷酸二酯酶(2,3-cyclic nucleopide 3-phosphdiesterase,CNPase)蛋白表达。结果: β-榄香烯干预组小鼠视神经的炎症反应较模型组明显减轻,正常髓鞘蛋白CNPase的表达较模型组增加(31.8±1.0 vs 10.6±0.7,P<0.05),轴索损害的标志物β-APP蛋白的表达较模型组减少(80.4±9.4 vs 182.7±9.1, P<0.05)。结论: β-榄香烯可保护EAE小鼠视神经的髓鞘及轴索损害。

关键词: β-榄香烯, 实验性变态反应性脑脊髓炎, β淀粉样前体蛋白, 2,3-环核苷3磷酸二酯酶

Abstract: AIM: To investigate the therapeutic effect of β-elemene on early optic neuritis in experimental allergic encephalomyelitis (EAE)mice. METHODS: The morphological changes of optic nerve in EAE group and β-elemene treated group were observed by morphology;the expression of β-amyloid precursor protein(β-APP)and 2,3-cyclic nucleopide 3-phosphdiesterase(CNPase) proteins were detected by immunohistochemistry. RESULTS: Compared with the EAE model group,the inflammation of optic nerve in β-elemene treated group was reduced, the expressions of CNPase were increased(31.8±1.0 vs 10.6±0.7, P<0.05)and the expressions of β-APP were decreased(80.4±9.4 vs 182.7±9.1, P<0.05)in β-elemene treated group. CONCLUSION: β-elemene can protect the optic nerve myelin and axon from the damage in EAE mice.

Key words: β-elemene, Experimental allergic encephalomyelitis, β-amyloid precursor protein, 2,3-cyclic nucleopide 3-phosphdiesterase

中图分类号:

R965.2

张荣伟, 陈蕾. β-榄香烯对早期实验性变态反应性脑脊髓炎小鼠视神经炎的治疗作用[J]. 中国临床药理学与治疗学, 2010, 15(10): 1128-1132.

ZHANG Rong-wei, CHEN Lei. Therapeutic effect of β-elemene on early optic neuritis in experimental allergic encephalomyelitis mice[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2010, 15(10): 1128-1132.

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