阿司匹林预防失败脑梗死患者的影响因素分析

中国临床药理学与治疗学 ›› 2010, Vol. 15 ›› Issue (10): 1148-1151.

阿司匹林预防失败脑梗死患者的影响因素分析

茅新蕾¹, 韩丽雅¹, 黄向东¹, 管朝红¹, 颜雪琴², 陈卫东²

¹温州市第二人民医院神经内科, ²温州医学院附属第二医院神经内科,温州 325000,浙江

收稿日期:2010-08-26 修回日期:2010-10-11 发布日期:2020-09-16
通讯作者: 陈卫东,男,教授,主任医师,从事神经内科工作。Tel: 0577-88879148 E-mail: weyylw@yahoo.com.cn
作者简介:茅新蕾,男,硕士研究生,主治医师,从事神经内科工作。Tel: 0577-88070291 E-mail: nantongmxl@sina.com
基金资助:
浙江省医药卫生科学研究基金(2006A107)

Analysis on the influencing factors of cerebral infarction patients with aspirin prevention failure

MAO Xin-lei¹, HAN Li-ya¹, HUANG Xiang-dong¹, GUAN Chao-hong¹, YAN Xue-qin², CHEN Wei-dong²

¹Second People's Hospital of Wenzhou City, ²Second Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, Zhejiang, China

Received:2010-08-26 Revised:2010-10-11 Published:2020-09-16

摘要/Abstract

摘要： 目的: 探讨阿司匹林预防失败脑梗死患者的影响因素。方法: 收集139例阿司匹林预防失败的脑梗死患者及24例长期规律服用阿司匹林的社区体检者,采集病史,检测身高、体重、血糖、血脂、血常规等指标,其中60例无心房颤动脑梗死患者及24例社区体检者检测尿11-去氢-血栓素B₂(11-DH-TXB₂)浓度。比较两组间各临床因素。结果: 与对照组相比,阿司匹林预防失败脑梗死患者男性、吸烟、既往脑梗死病史、心房颤动比例、尿11-DH-TXB₂浓度显著升高,高密度脂蛋白胆固醇(HDL-C)明显降低。Logistic回归显示既往脑梗死病史、尿11-DH-TXB₂浓度与阿司匹林预防失败密切相关。结论: 男性、吸烟、既往脑梗死病史、心房颤动、HDL-C降低与阿司匹林预防失败有关,阿司匹林抵抗是阿司匹林预防失败的一个重要危险因素。

关键词: 脑梗死, 阿司匹林, 阿司匹林抵抗

Abstract: AIM: To investigate the influencing factors of cerebral infarction patients with aspirin prevention failure. METHODS: 139 cerebral infarction patients with aspirin prevention failure and 24 community health examination cases who were regularly administered aspirin for long-term, were enrolled in the study. Everybody's medical history was recorded. Medical examinations included the measurement of weight, height, fasting blood lipid, glucose concentrations, and blood routine. The concentration of urinary 11-dehydrothromboxane B₂ of 60 patients without atrial fibrillation and 24 community health examination cases were determined. The clinical influencing factors of patients with aspirin prevention failure were compared with the controls. RESULTS: As compared with the controls, there were statistically significant differences in percentage of male, smoking, previous cerebral infarction, atrial fibrillation, high-density lipoprotein cholesterol concentrations and urinary 11-dehydrothromboxane B₂ concentrations(P<0.05). The results of logistic regression showed that there were significant correlation between aspirin failures and previous cerebral infarction, urine 11-DH-TXB₂ concentrations. CONCLUSION: It is suggested that male, smoking, previous cerebral infarction, atrial fibrillation, low high-density lipoprotein cholesterol are risk factors of aspirin failures. Aspirin resistance is an important risk factor for aspirin failures.

Key words: Cerebral infarction, Aspirin, Aspirin resistance

中图分类号:

R743.3

茅新蕾, 韩丽雅, 黄向东, 管朝红, 颜雪琴, 陈卫东. 阿司匹林预防失败脑梗死患者的影响因素分析[J]. 中国临床药理学与治疗学, 2010, 15(10): 1148-1151.

MAO Xin-lei, HAN Li-ya, HUANG Xiang-dong, GUAN Chao-hong, YAN Xue-qin, CHEN Wei-dong. Analysis on the influencing factors of cerebral infarction patients with aspirin prevention failure[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2010, 15(10): 1148-1151.

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