欢迎访问《中国临床药理学与治疗学》杂志官方网站,今天是

中国临床药理学与治疗学 ›› 2010, Vol. 15 ›› Issue (10): 1166-1169.

• 药物治疗学 • 上一篇    下一篇

拉米夫定停药后复发病例的临床特征

彭官清, 张长, 刘雪峰   

  1. 温州医学院附属温岭医院感染科,温岭 317500,浙江
  • 收稿日期:2010-07-26 修回日期:2010-09-18 发布日期:2020-09-16
  • 通讯作者: 张长,男,主任医师,研究方向:病毒性肝炎。Tel: 0576-86013880 E-mail: WLZC0812@163.com
  • 作者简介:彭官清,男,医师,研究方向:感染性疾病。Tel: 13958608272 E-mail: 501162748@qq.com

Clinical character of patients relapsed after withdrawal with lamivudine therapy

PENG Guan-qing, ZHANG Chang, LIU Xue-feng   

  1. Department of Infections Disease, the Affiliated Wenling Hospital of Wenzhou Medical College, Wenling 317500, Zhejiang, China
  • Received:2010-07-26 Revised:2010-09-18 Published:2020-09-16

摘要: 目的: 观察拉米夫定治疗获得完全应答和部分应答的患者,停药后复发病例的临床特征。方法: 160例完全应答者和35例部分应答者停用拉米夫定后继续监测。肝功能每月检测一次,HBV DNA和HBsAg、抗HBs、HBeAg、抗HBe、抗HBc每3个月检测一次。并详细记录病情及再治疗结果。结果: 完全应答者和部分应答者停药后HBV DNA复发率分别为 30.6%和 85.7%,两者比较差异有统计学意义(χ2=36.164,P<0.001)。ALT复发率分别为 28.75%(46/160)和 82.9% (29/35),差异有统计学意义(χ2=32.645,P<0.001)。停药后6个月内复发率部分应答者(80%,24/30)高于完全应答者(53.1%,26/49)。疗程长复发率相对较低。完全应答者复发病例病情较轻。停拉米夫定后定期随访,及时处理,预后良好。结论: 拉米夫定治疗获得完全应答者复发率低,复发后病情较轻,疗程长复发率相对较低,部分应答者 一般不建议停药。

关键词: 拉米夫定, 复发病例, 临床特征, 慢性乙型肝炎

Abstract: AIM: To investigate the clinical character of patients who had achieved complete or partial response relapsed after withdrawal with lamivudine therapy. METHODS: 160 patients with complete response and 35 patients with partial response continue to be monitored after withdrawal with lamivudine therapy.The liver function was checked once a month, the levels of HBV DNA, HBsAg, anti-HBs, HBeAg, anti-HBe and anti-HBc were tested once every 3 months. And detailed record of the condition and re-treatment outcomes. RESULTS: The relapse rates of HBV-DNA were 30.6% in the complete response group and 85.7% in the partial response group. The difference was statistically significant (χ2=36.164, P<0.001). ALT recurrence rate were 28.75% (46/160) and 82.9% (29/35), the difference was statistically significant (χ2=32.645, P<0.001). In 6 months after withdrawal, the relapse rates of the patients were 80% in the complete response group and 53.1% in the partial response group. With a long course, the recurrence rate was relatively low. The relapsed patients who had achieved complete response were mild. Lamivudine withdrawal with the long-term follow-up, timely treatment, prognosis was good. CONCLUSION: The relapse rate of the patients who had achieved complete response is lower. The state of illness is better in the patients who had achieved complete response, whereas, the treatment of the patients who had achieved partial response with lamivudine should not be discontinue.

Key words: Lamivudine, Relapse case, Clinical character, Chronic hepatitis B

中图分类号: