依达拉奉对单肺通气患者围术期细胞因子IL-6、IL-8及其mRNA表达的影响

中国临床药理学与治疗学 ›› 2010, Vol. 15 ›› Issue (3): 326-330.

依达拉奉对单肺通气患者围术期细胞因子IL-6、IL-8及其mRNA表达的影响

帅训军¹, 宫倩红², 艾登斌¹, 付世欧¹

¹青岛市市立医院麻醉科, 青岛 266011,山东;
²中国海洋大学医药学院生物技术室,青岛 266003,山东

收稿日期:2010-01-07 修回日期:2010-03-07 发布日期:2020-10-14
通讯作者: 艾登斌,男,教授,硕士生导师,主要从事麻醉生理、药理及疼痛机制的研究。E-mail: aidengbin@hotmail.com
作者简介:帅训军,男,硕士,副主任医师,主要从事麻醉病理生理及药理的研究。 Tel: 13698699472 E-mail: shjch@163.com
基金资助:
青岛市卫生局基金资助项目(2008-wszd016)

Effects of edaravone on interleukin-6,-8 and expression of their mRNA in patients undergoing one lung ventilation

SHUAI Xun-jun¹, GONG Qian-hong², AI Deng-bin¹, FU Shi-ou¹

¹Department of Anesthesiology, Qingdao Municipal Hospital, Qingdao 266011, Shandong, China;
²School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, Shandong, China

Received:2010-01-07 Revised:2010-03-07 Published:2020-10-14

摘要/Abstract

摘要： 目的: 观察依达拉奉对单肺通气患者围术期炎性细胞因子IL-6、IL-8及其mRNA表达的影响。方法: 择期拟行肺叶切除术肺癌患者24例,ASAⅠ级或Ⅱ级,年龄48～67岁,随机分为2组:对照组(C组)和依达拉奉组(E组),每组12例。麻醉诱导:两组均静脉注射咪唑安定 0.03 mg/kg、芬太尼 3 μg/kg,吸入8%七氟醚。麻醉诱导后,E组给予依达拉奉 0.5 mg/kg; C组给予等量生理盐水。麻醉维持:间断静脉注射维库溴铵 0.04～0.08 mg/kg、芬太尼 0.05～0.1 mg,七氟醚呼气末浓度维持在 1.8%～2.7%。两组均在麻醉后切皮前(T₁)、膨肺后 60 min(T₂)、术后 1 h(T₃)采取血样测定白细胞介素IL-6、IL-8血浆浓度及其mRNA表达。结果: 与T₁比较,两组IL-6、IL-8血浆浓度及其mRNA表达于T_2-3 明显上升(P＜0.05);与C组相比,E组IL-6、IL-8血浆浓度及其mRNA表达于T_2-3显著低于C组(P＜0.05)。结论: 依达拉奉应用于单肺通气患者可有效抑制机体促炎细胞因子的生成和释放。

关键词: 依达拉奉, 单肺通气, IL-6, IL-8, mRNA

Abstract: AIM: To investigate the effects of edaravone on interleukin(IL)-6,-8 and expression of their mRNA in patients undergoing one lung ventilation(OLV) METHODS: Twenty-four ASA Ⅰ or Ⅱ patients with lung cancer of both sexes aged 48-67 yr undergoing elective lung resection were randomly divided into two groups (n=12 each): Control group (C) and Edaravone group (E). Anesthesia was induced with midazolam 0.03 mg/kg, Fentanyl 3 μg/kg and 8% Sevoflurane, and maintained with intermittent i.v. boluses of vecuronium 0.04-0.08 mg/kg, Fentanyl 0.05-0.1 mg and 1.8%-2.7% Sevoflurane in two groups. Group E was received edaravone 0.5 mg/kg after induction of anesthesia. Blood sample were taken before skin incision (T₁), 60 min after lungs were inflated(T₂)and 1 h after surgery(T₃) for determination of plasma IL-6, IL-8 concentration and expression of their mRNA. RESULTS: The levels of IL-6, IL-8 and their mRNA were all significantly increased at T_2-3 in both group than at T₁(P＜0.05); but the levels of IL-6, IL-8 and their mRNA were lower at T_2-3 in group E than those in group C(P＜0.05). CONCLUSION: Edaravone is effective in reducing inflammatory response in patients undergoing OLV.

Key words: Edaravone, One lung ventilation, Interleukin-6, Interleukin-8, mRNA

中图分类号:

R734.2

帅训军, 宫倩红, 艾登斌, 付世欧. 依达拉奉对单肺通气患者围术期细胞因子IL-6、IL-8及其mRNA表达的影响[J]. 中国临床药理学与治疗学, 2010, 15(3): 326-330.

SHUAI Xun-jun, GONG Qian-hong, AI Deng-bin, FU Shi-ou. Effects of edaravone on interleukin-6,-8 and expression of their mRNA in patients undergoing one lung ventilation[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2010, 15(3): 326-330.

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