关键词: 冠心病, 稳定型心绞痛, 内皮功能, 活血化瘀

Abstract: AIM: To observe the effects and comparison of promoting the blood flow of Chinese formulated products on endothelial function in chronic stable angina. METHODS: 200 chronic stable angina patients were randomized to Danshen root, Ginkgo leaf, Troxerutin, or placebo and treated for 4 weeks. The FMD and NMD were measured by echocardiography. The level of ET-1 in plasma was measured by enzyme linked immunosorbent assay(ELISA). The level of NO in plasma was measured by nitrate reductase assay. All the data will be collected before and after treatment to analyze the effects of Chinese formulated products of endothelial function. RESULTS: Compared with the placebo group, before and after treatment of Danshen Pill group and venoruton group have a large change in FMD values (P<0.05), before and after treatment of Danshen Pill group,venoruton group and the Ginkgo biloba group NMD have a large value change (P<0.05), before and after treatment of Danshen Pill group, Ginkgo biloba group and venoruton group have a large ET value change (P<0.05), of which the Danshen Pill group, Ginkgo biloba group the largest group followed by Venoruton; with the placebo group, venoruton group, before and after treatment with a large group of Danshen Dropping Pill NO value change (P<0.05); of which Danshen Dropping Pill group of the largest ginkgo biloba group, followed by venoruton group. CONCLUSION: The Chinese formulated products of promoting the blood flow can improve the endothelial function in chronic stable angina patients, and Fufang Danshen Diwan is the most effective Chinese formulated product of these three drugs.

Key words: Coronary artery disease, Chronic stable angina, Endothelial function, Promoting the blood flow