不同时间给予比索洛尔对非杓型原发性高血压患者肾素-血管紧张素-醛固酮系统的影响

中国临床药理学与治疗学 ›› 2011, Vol. 16 ›› Issue (1): 101-104.

不同时间给予比索洛尔对非杓型原发性高血压患者肾素-血管紧张素-醛固酮系统的影响

刘华强¹, 闫美兴¹, 王少华¹, 孙晓蕾²

¹青岛市市立医院药学部,青岛 266011,山东;
²青岛大学医学院,青岛 266021,山东

收稿日期:2010-12-23 修回日期:2011-01-15 发布日期:2020-09-16
通讯作者: 王少华,女,学士,主任药师,硕导,研究方向:临床药理学、药事管理、药物临床试验。Tel: 0532-82789191
作者简介:刘华强,男,学士,药师,研究方向:临床药学。Tel: 0532-82789192 E-mail: lhq001_1981@126.com
基金资助:
山东省卫生厅立项课题(2007hw005)

Effects of bisoprolol with different drug administration time on the renin-angiotension-aldosterone system of non-dippers hypertension

LIU Hua-qiang¹,YAN Mei-xing¹,WANG Shao-hua¹,SUN Xiao-lei²

¹Department of Pharmacy, Qingdao Municipal Hospital, Qingdao 266011,Shandong,China;
²Qingdao University Medical College,Qingdao 266011,Shandong,China

Received:2010-12-23 Revised:2011-01-15 Published:2020-09-16

摘要/Abstract

摘要： 目的: 探讨不同时间给予比索洛尔对非杓型原发性高血压患者肾素-血管紧张素-醛固酮系统(RAAS)的影响。方法: 选择非杓型原发性高血压病患者60例,采取随机平行对照试验,观察比索洛尔每日早晨(8︰00)给药2.5～10 mg、比索洛尔每日夜间(20︰00)给药 2.5～10 mg 治疗8周前后分别检测血浆肾素(Ren) 、血管紧张素Ⅱ(Ang Ⅱ) 、醛固酮(Ald) 浓度并进行分析评价。结果: 治疗后上述各指标较治疗前均明显降低,差异有统计学意义 (P<0.05)。两组间比较肾素指标无统计学差异(P>0.05),血管紧张素Ⅱ、醛固酮指标有统计学差异(P<0.05)。结论: 早晨或夜间服用比索洛尔均能降低患者肾素、血管紧张素Ⅱ和醛固酮浓度,晚上服用比索洛尔对血管紧张素Ⅱ和醛固酮的影响更为显著。

关键词: 比索洛尔, 非杓型高血压, 肾素-血管紧张素-醛固酮系统

Abstract: AIM: To explore effect of renin-angiotension-aldosterone system induced by bisoprolol with different time drug administration in patients with non-dipper hypertension.METHODS: The patients were randomly divided into two parallel groups. All patients were treated with bisoprolol. The first group were received bisoprolol at eight o'clock once-daily between 2.5 mg and 10 mg. The second group were received bisoprolol at twenty o'clock once-daily between 2.5 mg and 10 mg. The concentration of rennin,angiotension and aldosterone after 8 weeks' treatment were detected and evaluated.RESULTS: The concentration of rennin,angiotension and aldosterone after treatment were lower than before treatment in two groups(P<0.05). And there was no significant difference between two groups on the concentration of renin (P>0.05), but a significant difference on angiotension and aldosterone(P<0.05).CONCLUSION: Two methods of treatment can decrease the concentration of rennin,angiotension and aldosterone, but the non-dippers hypertension taked drug at eight o'clock has a signifcant effect on angiotension and aldosterone.

Key words: Bisoprolol, Non-dippers hypertension, Renin-angiotension-aldosterone system , , , ,

中图分类号:

R544.1

引用本文

刘华强, 闫美兴, 王少华, 孙晓蕾. 不同时间给予比索洛尔对非杓型原发性高血压患者肾素-血管紧张素-醛固酮系统的影响[J]. 中国临床药理学与治疗学, 2011, 16(1): 101-104.

LIU Hua-qiang,YAN Mei-xing,WANG Shao-hua,SUN Xiao-lei. Effects of bisoprolol with different drug administration time on the renin-angiotension-aldosterone system of non-dippers hypertension[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(1): 101-104.

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