不同时间服用比索洛尔治疗非杓型原发性高血压的疗效评价

中国临床药理学与治疗学 ›› 2011, Vol. 16 ›› Issue (3): 292-296.

不同时间服用比索洛尔治疗非杓型原发性高血压的疗效评价

孙晓蕾¹, 管军², 于忠祥², 王少华², 闫美兴², 刘华强²

¹青岛大学医学院,青岛 266021,山东;
²青岛市市立医院药学部,青岛 266011,山东

收稿日期:2010-12-13 修回日期:2011-02-12 出版日期:2011-03-26 发布日期:2011-05-18
通讯作者: 管军,男,主任医师,硕士生导师,研究方向:高血压冠心病。
作者简介:孙晓蕾,女,硕士研究生,研究方向:高血压冠心病。Tel: 15253232656 E-mail: leihua03@126.com
基金资助:
山东省卫生厅立项课题(2007hw005)

Effects of bisoprolol with different drug administration time on the blood pressure of non-dippers hypretension

SUN Xiao-lei¹, GUAN Jun², YU Zhong-xiang², WANG Shao-hua², YAN Mei-xing², LIU Hua-qiang²

¹Qingdao University Medical College,Qingdao 266011,Shandong,China;
²Department of Pharmacy, Qingdao Municipal Hospital, Qingdao 266011,Shandong,China

Received:2010-12-13 Revised:2011-02-12 Online:2011-03-26 Published:2011-05-18

摘要/Abstract

摘要： 目的: 观察不同给药时间分别给予比索洛尔对非杓型原发性高血压患者的降压疗效和血压节律恢复的影响。方法: 选取60例非杓型高血压患者,采取随机平行对照试验,观察比索洛尔(n=30)每日早晨(8∶00)给药2.5～10 mg、比索洛尔(n=30)每日夜间(20∶00)给药2.5～10 mg治疗8周后的降压疗效。结果: 两种给药方法均能降低非杓型高血压患者的全天血压(P<0.05)。两种给药方法在白天的血压控制上无统计学差异(P>0.05),但在夜间血压的控制上夜间服药降压效果具有统计学差异(P<0.05)。夜间服药在血压节律恢复方面优于早晨服药(P<0.05),早晨服药组有10例恢复杓型,夜间服药组有19例恢复杓型。结论: 比索洛尔的两种给药方式均能安全有效地降压,但对于非杓型高血压患者夜间服药优于早晨服药,更有利于血压节律的恢复。

关键词: 比索洛尔, 非杓型高血压, 杓型高血压, 血压昼夜节律

Abstract: AIM: To investigate the effect of bisoprolol with different time on blood pressure control and circadian variability of dipper blood pressure for patients with non-dipper hypertension.METHODS: The patients were randomly divided into two parallel groups. All patients were treated with bisoprolol. The first group took bisoprolol at eight o'clock once-daily between 2.5 mg and 10 mg. The second group took bisoprolol at twenty o'clock once-daily between 2.5 mg and 10 mg. The efficiency of the 8 weeks' treatment and the change of the 24 hours blood pressure were detected.RESULTS: Thebloodpressuresof thepatientsinbothgroups were decreased(P<0.05). And there was no significant difference between the two groups for the day BP decrease (P>0.05), but taking bisoprolol at first group had a better efficacy than that in the second group of the ninght BP. On the recovery diurnal rhythm of blood pressure the first group was better than that of second group (P<0.05). There were 10 hypertensive patients with non-dipper pattern of blood pressure changed into dipper pattern in the first group while there were 19 patients changed in the second group.CONCLUSION: Two methods of treatment can control the blood pressure safe and efficacy, but taking drug at eight o'clock is better for the non-dippers hypertension and the diurnal rhythm of blood pressure than taking at twenty o'clock.

Key words: Bisoprolol, Non-dippers hypertension, Dippers hypertension, Diurnal rhythm of blood pressure

中图分类号:

R544.1

孙晓蕾, 管军, 于忠祥, 王少华, 闫美兴, 刘华强. 不同时间服用比索洛尔治疗非杓型原发性高血压的疗效评价[J]. 中国临床药理学与治疗学, 2011, 16(3): 292-296.

SUN Xiao-lei, GUAN Jun, YU Zhong-xiang, WANG Shao-hua, YAN Mei-xing, LIU Hua-qiang. Effects of bisoprolol with different drug administration time on the blood pressure of non-dippers hypretension[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(3): 292-296.

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